1-[3-(4-Nitrophenoxy)propyl]piperidine

Base Information

• Chemical Name: 1-[3-(4-Nitrophenoxy)propyl]piperidine
• CAS No.: 92374-75-9
• Molecular Formula: C14H20N2O3
• Molecular Weight: 264.324
• DSSTox Substance ID: DTXSID40366096
• Wikidata: Q82151182
• Mol file: 92374-75-9.mol

Synonyms:1-[3-(4-nitrophenoxy)propyl]piperidine;92374-75-9;Cambridge id 5366327;SCHEMBL491607;DTXSID40366096;JEVKRDOAGIIPGY-UHFFFAOYSA-N;1-[3-(4-nitro-phenoxy)-propyl]-piperidine;AB00083195-01;SR-01000207231;SR-01000207231-1

Chemical Property of 1-[3-(4-Nitrophenoxy)propyl]piperidine

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 264.14739250
• Heavy Atom Count: 19
• Complexity: 266

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)CCCOC2=CC=C(C=C2)[N+](=O)[O-]

Technology Process of 1-[3-(4-Nitrophenoxy)propyl]piperidine

There total 9 articles about 1-[3-(4-Nitrophenoxy)propyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

piperidine (110-89-4) + 1-(3-Chloropropoxy)-4-nitrobenzene (79096-54-1) → 1-[3-(4-nitro-phenoxy)-propyl]-piperidine (92374-75-9)

Guidance literature:

With sodium carbonate; sodium iodide; In butan-1-ol; at 25 - 100 ℃; for 20h;

Reference yield: 82.0%

4-Fluoronitrobenzene (350-46-9,178603-76-4) → 1-[3-(4-nitro-phenoxy)-propyl]-piperidine (92374-75-9)

Guidance literature:

3-piperidinopropan-1-ol; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 1h;

4-Fluoronitrobenzene; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 15h; Product distribution / selectivity;

Reference yield: 62.0%

3-piperidinopropan-1-ol (104-58-5) + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → 1-[3-(4-nitro-phenoxy)-propyl]-piperidine (92374-75-9)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 40h; Product distribution / selectivity;

upstream raw materials:

piperidine

1-(3-Chloropropoxy)-4-nitrobenzene

4-nitro-phenol

4-Fluoronitrobenzene

Downstream raw materials:

4-(3-piperidin-1-ylpropoxy)phenylamine

C₂₇H₃₀N₆O

C₁₇H₂₂N₂O₂S₂

C₃₁H₃₁N₃O₄S₂