(5S)-5-cyclohexyl-2-Pyrrolidinone

Base Information

• Chemical Name: (5S)-5-cyclohexyl-2-Pyrrolidinone
• CAS No.: 926622-88-0
• Molecular Formula: C₁₀H₁₇NO
• Molecular Weight: 167.251
• Mol file: 926622-88-0.mol

Synonyms:

Chemical Property of (5S)-5-cyclohexyl-2-Pyrrolidinone

Chemical Property:

• Melting Point: 71-73 °C
• Boiling Point: 330.2±11.0 °C(Predicted)
• PKA: 16.62±0.40(Predicted)
• PSA: 29.10000
• Density: 1.036±0.06 g/cm3(Predicted)
• LogP: 2.17410

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5S)-5-cyclohexyl-2-Pyrrolidinone

There total 19 articles about (5S)-5-cyclohexyl-2-Pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C26H31NO2 → (S)-5-cyclohexylpyrrolidin-2-one (926622-88-0)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol;

DOI:10.15227/orgsyn.084.0001

Reference yield: 85.0%

ethyl 4-cyclohexyl-4-(dibenzylamino)-2-butynoate (872357-94-3) → (S)-5-cyclohexylpyrrolidin-2-one (926622-88-0)

Guidance literature:

With potassium hydroxide; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/j.tet.2005.08.064

Reference yield: 82.0%

(S)-ethyl 4-cyclohexyl-4-(hydroxy((R)-1-(2,4,6-triisopropylphenyl)ethyl)amino)butanoate (926622-74-4) → (S)-5-cyclohexylpyrrolidin-2-one (926622-88-0)

Guidance literature:

(S)-ethyl 4-cyclohexyl-4-(hydroxy((R)-1-(2,4,6-triisopropylphenyl)ethyl)amino)butanoate; With hydrogen; acetic acid; palladium on activated charcoal; In ethyl acetate; for 4h;

at 220 ℃; for 5h;

DOI:10.1021/jo061976i

upstream raw materials:

Succinimide

cyclohexylmagnesium bromide

cyclohexylmethylamine

ethyl 4-cyclohexyl-4-(dibenzylamino)-2-butynoate

Refernces

• 1、 -. "TRICYCLIC MODULATORS OF TNF SIGNALING". Page/Page column 168. . Retrieved 2016/11/02.
• 2、 Zhao, Xiaodan,Dirocco, Daniel A.,Rovis, Tomislav. "N-heterocyclic carbene and Bronsted acid cooperative catalysis: Asymmetric synthesis of trans -γ-Lactams". supporting information; experimental part. p. 12466 - 12469. Retrieved 2011/09/16.