2-Fluoro-3-(trifluoromethyl)benzamide

Base Information

• Chemical Name: 2-Fluoro-3-(trifluoromethyl)benzamide
• CAS No.: 207853-60-9
• Molecular Formula: C8H5F4NO
• Molecular Weight: 207.127
• Hs Code.: 2924299090
• Mol file: 207853-60-9.mol

Synonyms:2-Fluoro-3-(trifluoromethyl)benzamide;

Chemical Property of 2-Fluoro-3-(trifluoromethyl)benzamide

Chemical Property:

• Vapor Pressure: 0.352mmHg at 25°C
• Melting Point: 94-97 °C
• Refractive Index: 1.462
• Boiling Point: 210.9 °C at 760 mmHg
• PKA: 14.58±0.50(Predicted)
• Flash Point: 81.4 °C
• PSA: 43.09000
• Density: 1.42 g/cm³
• LogP: 2.64370
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Fluoro-3-(trifluoromethyl)benzamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-3-(trifluoromethyl)benzamide

There total 3 articles about 2-Fluoro-3-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.9%

2-fluoro-3-trifluoromethylbenzoyl chloride (208173-19-7) → 2-fluoro-3-(trifluoromethyl)benzamide (207853-60-9)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; at 2 ℃; for 2h; Temperature;

Reference yield:

1-fluoro-2-trifluoromethylbenzene (392-85-8) → 2-fluoro-3-(trifluoromethyl)benzamide (207853-60-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.67 h / -80 °C / Inert atmosphere

1.2: 2 h / Inert atmosphere

2.1: thionyl chloride / 3 h / 90 °C

3.1: ammonium hydroxide / tetrahydrofuran / 2 h / 2 °C

With ammonium hydroxide; thionyl chloride; lithium diisopropyl amide; In tetrahydrofuran;

Reference yield:

2-fluoro-3-(trifluoromethyl)benzoic acid (115029-22-6) → 2-fluoro-3-(trifluoromethyl)benzamide (207853-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 3 h / 90 °C

2: ammonium hydroxide / tetrahydrofuran / 2 h / 2 °C

With ammonium hydroxide; thionyl chloride; In tetrahydrofuran;

upstream raw materials:

1-fluoro-2-trifluoromethylbenzene

2-fluoro-3-(trifluoromethyl)benzoic acid

2-fluoro-3-trifluoromethylbenzoyl chloride

Downstream raw materials:

2-fluoro-3-(trifluoromethyl)aniline