1,2,3-trimethoxy-10-methylacridin-9(10H)-one

Base Information

• Chemical Name: 1,2,3-trimethoxy-10-methylacridin-9(10H)-one
• CAS No.: 13082-16-1
• Molecular Formula: C₁₇H₁₇NO₄
• Molecular Weight: 299.326
• Mol file: 13082-16-1.mol

Synonyms:9-Acridanone,1,2,3-trimethoxy-10-methyl- (7CI,8CI); 1,2,3-Trimethoxy-10-methyl-9-acridanone;1,2,3-Trimethoxy-10-methylacridone; 1,2,3-Trimethoxy-N-methylacridon; NSC 94651

Chemical Property of 1,2,3-trimethoxy-10-methylacridin-9(10H)-one

Chemical Property:

• Vapor Pressure: 1.69E-09mmHg at 25°C
• Boiling Point: 483.4°Cat760mmHg
• Flash Point: 246.1°C
• Density: 1.218g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3-trimethoxy-10-methylacridin-9(10H)-one

There total 23 articles about 1,2,3-trimethoxy-10-methylacridin-9(10H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

phenyl(2,3,4-trimethoxy-6-methylaminophenyl)methanone (1454253-75-8) → 1,2,3-Trimethoxy-N-methylacridon (13082-16-1)

Guidance literature:

With [2,2]bipyridinyl; copper(l) iodide; oxygen; In N,N-dimethyl acetamide; at 160 ℃; for 12h; Sealed tube;

DOI:10.1002/chem.201203859

Reference yield: 85.0%

1,2,3-trimethoxyacridin-9(10H)-one (33130-09-5) + methyl iodide (74-88-4) → 1,2,3-Trimethoxy-N-methylacridon (13082-16-1)

Guidance literature:

1,2,3-trimethoxyacridin-9(10H)-one; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.04.127

Reference yield: 85.0%

1,3-dimethoxy-2-hydroxy-10-methyl-9(10H)-acridinone (132216-13-8) + methyl iodide (74-88-4) → 1,2,3-Trimethoxy-N-methylacridon (13082-16-1)

Guidance literature:

With potassium carbonate; In acetone; for 2h; Heating;

DOI:10.1007/BF00809777

upstream raw materials:

9-chloro-1,2,3-trimethoxyacridine

1,3-dimethoxy-2-hydroxy-10-methyl-9(10H)-acridinone

dimethyl sulfate

2,3,4-trimethoxybromobenzene

Downstream raw materials:

arborinine