1-Piperazinecarboxylic acid, 4-[4-[[[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3 -nitrophenyl]sulfonyl]amino]carbonyl]phenyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperazinecarboxylic acid, 4-[4-[[[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3 -nitrophenyl]sulfonyl]amino]carbonyl]phenyl]-, 1,1-dimethylethyl ester
CAS No.:926933-96-2
Molecular Formula:C₃₄H₄₄N₆O₇S₂
Molecular Weight:712.891
Hs Code.:

1-Piperazinecarboxylic acid,
4-[4-[[[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3
-nitrophenyl]sulfonyl]amino]carbonyl]phenyl]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of 1-Piperazinecarboxylic acid, 4-[4-[[[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3 -nitrophenyl]sulfonyl]amino]carbonyl]phenyl]-, 1,1-dimethylethyl ester

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Technology Process of 1-Piperazinecarboxylic acid, 4-[4-[[[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3 -nitrophenyl]sulfonyl]amino]carbonyl]phenyl]-, 1,1-dimethylethyl ester

There total 1 articles about 1-Piperazinecarboxylic acid, 4-[4-[[[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3 -nitrophenyl]sulfonyl]amino]carbonyl]phenyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 162046-66-4
4-(4-(1,1-dimethylethoxycarbonyl)piperazin-1-yl)benzoic acid

: 406233-35-0
4-(((1R)-3-(dimethylamino)-1-((phenylthio)methyl)propyl)amino)-3-nitrobenzenesulfonamide

: 926933-96-2
(R)-tert-butyl 4-(4-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonylcarbamoyl)phenyl)piperazine-1-carboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 12h;
DOI:10.1021/jm061152t

Reference yield:

: 926933-96-2
(R)-tert-butyl 4-(4-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonylcarbamoyl)phenyl)piperazine-1-carboxylate

: 4-(3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-3-nitro-N-(4-piperazin-1-yl-benzoyl)-benzenesulfonamide; hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane;
DOI:10.1021/jm061152t

Reference yield:

: 926933-96-2
(R)-tert-butyl 4-(4-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonylcarbamoyl)phenyl)piperazine-1-carboxylate

: N-(4-(4-(2-(cyclohexylamino)benzyl)piperazin-1-yl)benzoyl)-4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)propyl)amino)-3-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / dioxane

2: 18 percent / DIPEA; sodium triacetoxyborohydride / methanol; CH₂Cl₂ / 16 h

With hydrogenchloride; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm061152t