2-Pyridineethanamine, N-phenyl-N-[2-(2-pyridinyl)ethyl]-

Base Information

• Chemical Name: 2-Pyridineethanamine, N-phenyl-N-[2-(2-pyridinyl)ethyl]-
• CAS No.: 92733-94-3
• Molecular Formula: C20H21N3
• Molecular Weight: 303.407
• DSSTox Substance ID: DTXSID10478231
• Mol file: 92733-94-3.mol

Synonyms:92733-94-3;2-Pyridineethanamine, N-phenyl-N-[2-(2-pyridinyl)ethyl]-;N,N-bis(2-pyridin-2-ylethyl)aniline;DTXSID10478231;N,N-bis[2-(2-pyridyl)ethyl]aniline

Chemical Property of 2-Pyridineethanamine, N-phenyl-N-[2-(2-pyridinyl)ethyl]-

Chemical Property:

• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 303.173547683
• Heavy Atom Count: 23
• Complexity: 292

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)N(CCC2=CC=CC=N2)CCC3=CC=CC=N3

Technology Process of 2-Pyridineethanamine, N-phenyl-N-[2-(2-pyridinyl)ethyl]-

There total 1 articles about 2-Pyridineethanamine, N-phenyl-N-[2-(2-pyridinyl)ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6) + aniline (62-53-3) → N-phenyl-2'-aminoethyl-2-pyridine (6312-12-5) + N,N-bis[2-(pyridine-2-yl)ethyl]aniline (92733-94-3)

Guidance literature:

With betaine; sodium hydroxide; ortho-chlorobenzoic acid; In water; at 70 ℃; for 24h; Reagent/catalyst;

DOI:10.1007/s00706-020-02660-z

Reference yield: 79.0%

tetrakis(actonitrile)copper(I) hexafluorophosphate (64443-05-6) + N,N-bis[2-(pyridine-2-yl)ethyl]aniline (92733-94-3) → {Cu(phenyl-bis(2-pyridylethyl)amine)}PF6 (144157-51-7)

Guidance literature:

In dichloromethane; under Ar; equimolar quantities; stirring for 2 h;; ppt. by addn. of Et2O; recrystd. from CH2Cl2/Et2O; elem. anal.;;

Reference yield:

N,N-bis[2-(pyridine-2-yl)ethyl]aniline (92733-94-3) → 4-[(4,5-dimethoxy-2-nitrosophenyl)carbonyl]-N,N-bis[2-(pyridine-2-yl)ethyl]aniline (1384522-75-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine / dichloromethane / 12 h / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran; dichloromethane / 0.5 h

3: ethanol / Photolysis

With 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1039/c2dt30135k

upstream raw materials:

2-vinylpyridine

aniline

Downstream raw materials:

{Cu(phenyl-bis(2-pyridylethyl)amine)}PF₆

4-[(4,5-dimethoxy-2-nitrosophenyl)carbonyl]-N,N-bis[2-(pyridine-2-yl)ethyl]aniline

(4-{bis[2-(pyridine-2-yl)ethyl]amino}phenyl)(4,5-dimethoxy-2-nitrophenyl)methanol