Diflucortolone

Base Information

Chemical Name:Diflucortolone
CAS No.:2607-06-9
Molecular Formula:C22H28F2O4
Molecular Weight:394.459
Hs Code.:2937229000
European Community (EC) Number:220-022-6
UNII:K253365DXI
DSSTox Substance ID:DTXSID50180705
Nikkaji Number:J7.627I
Wikipedia:Diflucortolone
Wikidata:Q5275453
NCI Thesaurus Code:C87231
Metabolomics Workbench ID:152149
ChEMBL ID:CHEMBL509924
Mol file:2607-06-9.mol

Synonyms:Diflucortolone;Ro 10 7614;Ro 10-7614;Ro 107614

Suppliers and Price of Diflucortolone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
Diflucortolone
25 mg
$ 1190.00

American Custom Chemicals Corporation
DIFLUCORTOLONE 95.00%
10G
$ 2771.14

American Custom Chemicals Corporation
DIFLUCORTOLONE 95.00%
5G
$ 1722.11

American Custom Chemicals Corporation
DIFLUCORTOLONE 95.00%
1G
$ 867.12

AHH
Diflucortolone 97%
5g
$ 350.00

Total 31 raw suppliers

Chemical Property of Diflucortolone

Chemical Property:

Appearance/Colour:A white to pink crystalline
Vapor Pressure:0mmHg at 25°C
Melting Point:220oC
Refractive Index:1.562
Boiling Point:534.005 °C at 760 mmHg
PKA:12.90±0.70(Predicted)
Flash Point:276.756 °C
PSA：74.60000
Density:1.295 g/cm³
LogP:2.72880
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly, Sonicated), DMSO (Slightly)
XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:394.19556569
Heavy Atom Count:28
Complexity:791

Purity/Quality:

99% ^*data from raw suppliers

Diflucortolone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1C(=O)CO)C)O)F)C)F
Isomeric SMILES:C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)CO)C)O)F)C)F
Uses Glucocorticoid. . Difluocortolone is used as a topical therapy in the treatment of pediatric tinea corporis; a common mycotic infection in children.
Therapeutic Function Antiinflammatory

Technology Process of Diflucortolone

There total 6 articles about Diflucortolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 2135-17-3
flumetasone

: 2607-06-9
6α,9-difluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione

Guidance literature:: With trimethylsilyl iodide; In acetonitrile; at -20 ℃; for 2h; Inert atmosphere;

Reference yield:

: diflucortolone Valerate

: 2607-06-9
6α,9-difluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione

Guidance literature:: With water; potassium hydrogencarbonate; In 1,4-dioxane; methanol; at 20 ℃; for 72h;
DOI:10.1016/j.bmc.2012.10.036

Reference yield:

: 4571-51-1
9β,11-epoxy-6α-fluoro-16α-methyl-17,21-dihydroxy-1,4-diene-3,20-dione 21-acetate

: 2607-06-9
6α,9-difluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; water / methanol / 10 h

2: hydrogen fluoride / 5 h / -15 - -10 °C

3: trimethylsilyl iodide / acetonitrile / 2 h / -20 °C / Inert atmosphere

With trimethylsilyl iodide; hydrogen fluoride; water; potassium carbonate; In methanol; acetonitrile;