6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

Base Information Edit

Chemical Name:6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
CAS No.:2135-17-3
Molecular Formula:C22H28F2O5
Molecular Weight:410.458
Hs Code.:29144000
NSC Number:54702
DSSTox Substance ID:DTXSID30859700
ChEMBL ID:CHEMBL2007346
Mol file:2135-17-3.mol

Synonyms:6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione;6.alpha.-Fluorodexamethasone;NSC54702;MFCD00056464;CHEMBL2007346;DTXSID30859700;AKOS025149901;NCI60_004347;SY074151;FT-0626440;FT-0666805;U 10974;6.alpha.,9.alpha.-Difluoro-16.alpha.-methylprednisolone;6.alpha.,17,21-trihydroxy-16.alpha.-methylpregna-1,4-diene-3,20-dione;Pregna-1,20-dione, 6.alpha.,9-difluoro-11.beta.,17,21-trihydroxy-16.alpha.-methyl-;Pregna-1,20-dione, 6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6.alpha.,11.beta.,16.alpha.)-

Suppliers and Price of 6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Flumethasone
500ul
$ 654.00

Usbiological
Flumethasone
500ul
$ 523.00

TRC
Flumethasone
100mg
$ 95.00

Sigma-Aldrich
Flumethasone
50mg
$ 87.90

Sigma-Aldrich
Flumethasone
500mg
$ 600.00

Medical Isotopes, Inc.
Flumethasone
1 g
$ 890.00

Crysdot
Flumethasone 98+%
100mg
$ 49.00

Crysdot
Flumethasone 98+%
250mg
$ 99.00

Chem-Impex
Flumetasone,≥98%(HPLC) ≥98%(HPLC)
1G
$ 605.70

Chem-Impex
Flumetasone,98%(HPLC) 98%(HPLC)
200MG
$ 152.32

Total 192 raw suppliers

Chemical Property of 6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione Edit

Chemical Property:

Appearance/Colour:White crystalline powder
Vapor Pressure:2.33E-15mmHg at 25°C
Melting Point:237-240oC
Refractive Index:1.579
Boiling Point:569.8 °C at 760 mmHg
PKA:11.98±0.70(Predicted)
Flash Point:298.4 °C
PSA：94.83000
Density:1.36 g/cm³
LogP:1.84370
Storage Temp.:2-8°C
Solubility.:acetic acid: soluble10mg/mL
Water Solubility.:1mg/L(20 oC)
XLogP3:1.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:410.19048031
Heavy Atom Count:29
Complexity:839

Purity/Quality:

99% ^*data from raw suppliers

Flumethasone ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 40
Safety Statements: 22-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C)F
Description Flumethasone is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. Its mechanism of action is thought to inhibit arachidonic acids role in the biosynthesis of prostaglandins and leukotrienes. Flumethasone is active when it is not bound to the plasma protein transcortin. The drug flumethasone can be used to treat a variety of skin conditions, such as contact dermatitis, bug bites and eczema. Flumethasone is an agonist of glucocorticoid and mineralocorticoid receptors with EC50 values of 0.26 and 0.494 nM, respectively, in CV-1 cells expressing human receptors. In vitro, it inhibits the growth of UM-UC-3, TCC-SUP, and 5637 urothelial carcinoma cell lines at a concentration of 100 nM. Flumethasone (5 mg per animal) decreases tumor necrosis factor (TNF) production ex vivo in blood cells collected by bronchoalveolar lavage (BAL) from calves with experimentally-induced local lung inflammation. It also inhibits phytohemagglutinin-induced delayed hypersensitivity in calf skin. In vivo, flumethasone (5 μM) impairs cell cycle re-entry of cardiac cells seven days post cryo-injury to the heart and impairs cardiac regeneration in zebrafish.
Uses Flumethasone is an anti-inflammatory glucocorticoid used in veterinary practice and used as an anti-inflammatory for a variety of animals. It is commonly investigated for its effectiveness in animals to combat inflammatory symptoms caused by pathogens and to better understand inflammatory mechanisms. It is also used as to investigate novel techniques that detect and quantify steroid compounds within muscles. For the treatment of contact dermatitis, atopic dermatitis, exczema, psoriasis, diaper rash and other skin conditions. Flumethasone is a corticosteroid for topical use, in combination with Clioquinol for the treatment of otitis externa and otomycosis. Flumethasone shows fully 420 times the potency of cortisone in an animal model for anti-inflammatory activity. Flumethasone has been shown to exert anti-inflammtory effects by functioning as a glucocorticoid receptor agonist. Stimulating this receptor promotes inhibition of phospholipase A2 activity. This enzyme catalyzes arachidonic acid into eicosanoids most of which stimulate anti-inflammation mechanisms. A glucocorticoid. An anti-inflammatory topical anti-inflammatory corticosteroid A glucocorticoid. An anti-inflammatory.
Therapeutic Function Glucocorticoid, Antiinflammatory

Technology Process of 6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

There total 9 articles about 6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%