6-Benzyloxy-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid Methyl ester

Base Information

• Chemical Name: 6-Benzyloxy-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid Methyl ester
• CAS No.: 929028-73-9
• Molecular Formula: C18H15NO4
• Molecular Weight: 309.321
• Mol file: 929028-73-9.mol

Synonyms:methyl 6-benzyloxy-1,4-dihydro-4-oxoquinoline-2-carboxylate;QC-8467;

Chemical Property of 6-Benzyloxy-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid Methyl ester

Chemical Property:

• PSA: 68.39000
• LogP: 2.89370
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

Methyl6-(benzyloxy)-4-oxo-1,4-dihydroquinoline-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Benzyloxy-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid Methyl ester

There total 4 articles about 6-Benzyloxy-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

dimethyl 2-(4-benzyloxyphenyl)aminomaleate → methyl 6-benzyloxy-1,4-dihydro-4-oxoquinoline-2-carboxylate (929028-73-9)

Guidance literature:

In diphenylether; at 245 ℃; for 1.16667h; Inert atmosphere;

DOI:10.1021/ol403598k

Reference yield:

p-benzyloxyaniline (6373-46-2) → methyl 6-benzyloxy-1,4-dihydro-4-oxoquinoline-2-carboxylate (929028-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 2 h / Heating

2: diphenyl ether; various solvent(s) / 0.17 h / 240 °C

In methanol; diphenylether;

DOI:10.1016/j.bmcl.2006.10.033

Reference yield:

dimethyl acetylenedicarboxylate (762-42-5) → methyl 6-benzyloxy-1,4-dihydro-4-oxoquinoline-2-carboxylate (929028-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 2 h / Heating

2: diphenyl ether; various solvent(s) / 0.17 h / 240 °C

In methanol; diphenylether;

DOI:10.1016/j.bmcl.2006.10.033

upstream raw materials:

p-benzyloxyaniline

dimethyl acetylenedicarboxylate

Downstream raw materials:

6-benzyloxy-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid

methyl 6-(benzyloxy)-4-chloroquinoline-2-carboxylate

6-hydroxykynurenic acid

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