4-amino-2,6-dichloronicotinic acid

Base Information

• Chemical Name: 4-amino-2,6-dichloronicotinic acid
• CAS No.: 929288-22-2
• Molecular Formula: C₆H₄Cl₂N₂O₂
• Molecular Weight: 207.016
• Hs Code.: 2933399090
• Mol file: 929288-22-2.mol

Synonyms:4-Amino-2,6-dichloro-3-pyridinecarboxylic acid;4-amino-2,6-dichloronicotinic acid;3-Pyridinecarboxylic acid,4-amino-2,6-dichloro;QC-4558;

Chemical Property of 4-amino-2,6-dichloronicotinic acid

Chemical Property:

• PSA: 76.21000
• LogP: 2.25000
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-AMINO-2,6-DICHLORONICOTINIC ACID 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-?Amino-?2,?6-?dichloronicotinic Acid is a reagent used in the synthesis of pyrimidine based scaffolds.

Technology Process of 4-amino-2,6-dichloronicotinic acid

There total 4 articles about 4-amino-2,6-dichloronicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.8%

tert-butyl 4-(tert-butoxycarbonylamino)-2,6-dichloronicotinate (1044148-92-6) → 4-amino-2,6-dichloronicotinic acid (929288-22-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

4-(tert-butoxycarbonylamino)-2,6-dichloronicotinic acid (929288-17-5) → 4-amino-2,6-dichloronicotinic acid (929288-22-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2006.10.056

Reference yield:

tert-butyl (2,6-dichloropyridin-4-yl)carbamate (501907-61-5) → 4-amino-2,6-dichloronicotinic acid (929288-22-2)

Guidance literature:

Multi-step reaction with 2 steps

1: n-BuLi / diethyl ether / -78 - 20 °C

2: TFA / CH₂Cl₂ / 12 h / 20 °C

With n-butyllithium; trifluoroacetic acid; In diethyl ether; dichloromethane;

DOI:10.1016/j.tetlet.2006.10.056

upstream raw materials:

4-(tert-butoxycarbonylamino)-2,6-dichloronicotinic acid

tert-butyl (2,6-dichloropyridin-4-yl)carbamate

2,6-dichloro-[4]pyridylamine

tert-butyl 4-(tert-butoxycarbonylamino)-2,6-dichloronicotinate

Downstream raw materials:

7-chloro-4-ethoxy-2-methyl-5-phenyl-pyrido[4,3-d]pyrimidine

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