3,4-Dihydro-2h-thiochroMen-4-aMine

Base Information

• Chemical Name: 3,4-Dihydro-2h-thiochroMen-4-aMine
• CAS No.: 93192-72-4
• Molecular Formula: C9H11NS
• Molecular Weight: 165.25500
• Hs Code.: 2932999099
• Mol file: 93192-72-4.mol

Synonyms:thiochroman-4-amine;3,4-dihydro-2H-thiochromen-4-ylamine;4-amino-3,4-dihydro-1H-benzothiopyran;

Chemical Property of 3,4-Dihydro-2h-thiochroMen-4-aMine

Chemical Property:

• Boiling Point: 261.6±39.0 °C(Predicted)
• PKA: 8.65±0.20(Predicted)
• PSA: 51.32000
• Density: 1.153±0.06 g/cm3(Predicted)
• LogP: 2.88250

Purity/Quality:

97% ^*data from raw suppliers

3,4-Dihydro-2H-thiochromen-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Dihydro-2h-thiochroMen-4-aMine

There total 1 articles about 3,4-Dihydro-2h-thiochroMen-4-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

thiochroman-4-one oxime (15857-68-8) → 2,3,4,5-tetrahydro-benzo[b][1,4]thiazepine (40358-33-6) + 3,4-dihydro-2H-thiochromen-4-ylamine (93192-72-4)

Guidance literature:

With dichloroaluminum hydride; In diethyl ether; at 0 - 20 ℃; for 2h;

DOI:10.3390/molecules17067348

Reference yield:

C25H33N3O6 + 3,4-dihydro-2H-thiochromen-4-ylamine (93192-72-4) → C28H37N3O5S

Guidance literature:

C₂₅H₃₃N₃O₆; With 4-methyl-morpholine; isobutyl chloroformate; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;

3,4-dihydro-2H-thiochromen-4-ylamine; In N,N-dimethyl-formamide; for 16h;

Reference yield:

N2-((benzyloxy)carbonyl)-N6-(5-(tert-butoxy)-5-oxopentanethioyl)-L-lysine + 3,4-dihydro-2H-thiochromen-4-ylamine (93192-72-4) → 4-(((5S)-5-(((benzyloxy)carbonyl)amino)-6-oxo-6-(thiochroman-4-ylamino)hexyl)amino)-5-thioxopentanoic acid

Guidance literature:

N²-((benzyloxy)carbonyl)-N⁶-(5-(tert-butoxy)-5-oxopentanethioyl)-L-lysine; 3,4-dihydro-2H-thiochromen-4-ylamine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201709050

upstream raw materials:

thiochroman-4-one oxime