Benzeneacetic acid, 2-bromo-, butyl ester

Base Information

• Chemical Name: Benzeneacetic acid, 2-bromo-, butyl ester
• CAS No.: 93579-02-3
• Molecular Formula: C12H15BrO2
• Molecular Weight: 271.154
• Mol file: 93579-02-3.mol

Synonyms:

Chemical Property of Benzeneacetic acid, 2-bromo-, butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetic acid, 2-bromo-, butyl ester

There total 2 articles about Benzeneacetic acid, 2-bromo-, butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

boric acid tributyl ester (688-74-4) + carbon monoxide (201230-82-2) + 1-Bromo-2-bromomethyl-benzene (3433-80-5) → butyl 2-(2-bromophenyl)acetate (93579-02-3)

Guidance literature:

1,5-hexadienerhodium(I)-chloride dimer; at 75 ℃; under 760 Torr; Heating; overnight; other solvent;

DOI:10.1016/S0040-4039(01)91168-2

Reference yield: 66.0%

n-Butyl chloride (109-69-3) + potassium 2-bromophenylacetate (63071-77-2) → butyl 2-(2-bromophenyl)acetate (93579-02-3)

Guidance literature:

With tetrabutyl phosphonium bromide; potassium iodide; In N,N-dimethyl-formamide; at 120 ℃; for 17h; Schlenk technique; Inert atmosphere;

DOI:10.1055/s-0033-1341062

Reference yield:

butyl 2-(2-bromophenyl)acetate (93579-02-3) → butyl 2-(3-bromophenyl)-2-diazoacetate (1632260-39-9)

Guidance literature:

With 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 - 20 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1055/s-0033-1341062

upstream raw materials:

boric acid tributyl ester

carbon monoxide

1-Bromo-2-bromomethyl-benzene

n-Butyl chloride

Downstream raw materials:

butyl 2-(3-bromophenyl)-2-diazoacetate

Refernces

• 1、 Woell, James B.,Alper, Howard. "SYNTHESIS OF ESTERS BY RHODIUM(I) CATALYZED BORATE ESTER-BENZYLIC BROMIDE CARBONYLATION REACTIONS". . p. 3791 - 3794. Retrieved 2007/10/02.