PYRROLE-2,4-DICARBOXYLIC ACID

Base Information

• Chemical Name: PYRROLE-2,4-DICARBOXYLIC ACID
• CAS No.: 937-26-8
• Molecular Formula: C6H5NO4
• Molecular Weight: 155.10800
• Hs Code.: 2933990090
• Mol file: 937-26-8.mol

Synonyms:Pyrrol-2,4-dicarbonsaeure;Pyrrol-dicarbonsaeure-2,4;1H-Pyrrole-2,4-dicarboxylic acid;pyrrole-2,4-dicarboxylic acid;

Chemical Property of PYRROLE-2,4-DICARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 528.152oC at 760 mmHg
• Flash Point: 273.217oC
• PSA: 90.39000
• Density: 1.671g/cm3
• LogP: 0.41110

Purity/Quality:

99% ^*data from raw suppliers

1H-Pyrrole-2,4-dicarboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PYRROLE-2,4-DICARBOXYLIC ACID

There total 7 articles about PYRROLE-2,4-DICARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1H-pyrrole-2,4-dicarboxylic acid diethyl ester (55942-40-0) → pyrrole-2,4-dicarboxylic acid (937-26-8)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja01620a031

Reference yield:

γ-Formyl-α-ketoglutarsaeure-diaethylester-diaethylketal (109512-89-2) → pyrrole-2,4-dicarboxylic acid (937-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether; ethanolic NH₃ / Erwaermen des Reaktionsprodukts mit konz. H₂SO₄

2: ethanolic KOH

With potassium hydroxide; diethyl ether; ammonia;

DOI:10.1021/ja01620a031

Reference yield:

3-bromo-5-methyl-pyrrole-2,4-dicarboxylic acid diethyl ester (856197-66-5) → pyrrole-2,4-dicarboxylic acid (937-26-8)

Guidance literature:

Multi-step reaction with 5 steps

1: bromine; SO₂Cl₂; acetic acid / Reagens 4: Acetanhydrid; Erwaermen des Reaktionsgemisches mit H₂O

2: aqueous NaOH; aqueous KMnO

3: acetic acid; bromine

4: Raney nickel; ethanol; NaHCO₃ / 80 °C / 58840.6 Torr / Hydrogenation

5: ethanolic KOH

With potassium hydroxide; sodium hydroxide; sulfuryl dichloride; ethanol; bromine; nickel; sodium hydrogencarbonate; acetic acid;

upstream raw materials:

1H-pyrrole-2,4-dicarboxylic acid diethyl ester

3-bromo-5-methyl-pyrrole-2,4-dicarboxylic acid diethyl ester

5-bromo-3-chloro-pyrrole-2,4-dicarboxylic acid diethyl ester

3-chloro-5-formyl-pyrrole-2,4-dicarboxylic acid diethyl ester

Downstream raw materials:

pyrrole-2,4-dicarboxylic acid dimethyl ester