55942-40-0

Basic information

• Product Name: Diethyl 1H-pyrrole-2,4-dicarboxylate
• Synonyms: Diethyl 1H-pyrrole-2,4-dicarboxylate;Diethyl 1H-pyrrole-2,4-di...;2,4-diethyl 1H-pyrrole-2,4-dicarboxylate;1H-pyrrole-2,4-dicarboxylic acid diethyl ester
• CAS NO: 55942-40-0
• Molecular Formula: C₁₀H₁₃NO₄
• Molecular Weight: 211.21452
• Mol File: 55942-40-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 74-75 °C
• Boiling Point: 373.1±22.0 °C(Predicted)
• Appearance: /
• Density: 1.196±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.66±0.50(Predicted)
• CAS DataBase Reference: Diethyl 1H-pyrrole-2,4-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Diethyl 1H-pyrrole-2,4-dicarboxylate(55942-40-0)
• EPA Substance Registry System: Diethyl 1H-pyrrole-2,4-dicarboxylate(55942-40-0)

Safety Data

• Hazardous Substances Data: 55942-40-0(Hazardous Substances Data)

Usage

General Description

Diethyl 1H-pyrrole-2,4-dicarboxylate is a chemical compound with the molecular formula C10H13NO4. It is an ester derivative of pyrrole-2,4-dicarboxylic acid and is commonly used in organic synthesis as a building block for the production of various pharmaceuticals and agrochemicals. Diethyl 1H-pyrrole-2,4-dicarboxylate has a pyrrole ring structure with two carboxylate groups, and it is known for its mild, fruity odor. Diethyl 1H-pyrrole-2,4-dicarboxylate is a colorless to light yellow liquid that is slightly soluble in water and highly soluble in organic solvents. It is primarily used as a key intermediate in the synthesis of bioactive compounds and has potential applications in the pharmaceutical and agricultural industries.

Upstream product

• 623-47-2 propynoic acid ethyl ester 
• 3154-51-6 ethyl N-formylglycinate 
• 2199-43-1 ethyl 1H-pyrrole-2-carboxylate 
• 64-17-5 ethanol 
• 1310448-38-4 ethyl 4-(trichloroacetyl)-1H-pyrrole-2-carboxylate 
• 2999-46-4 Ethyl isocyanoacetate 
• 92286-09-4 4-chloro-pyrrole-2,3,5-tricarboxylic acid 3,5-diethyl ester 
• 91089-85-9 3-chloro-5-formyl-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 856197-66-5 3-bromo-5-methyl-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 79265-46-6 C₁₀H₁₅NO₃S 
• 140-88-5 ethyl acrylate 
• 103871-46-1 3-Ethoxycarbonylmethyl-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium; bromide 
• 105-56-6 ethyl 2-cyanoacetate 
• 50-00-0 formaldehyd 

Downstream Products

• 1310431-04-9 C₁₇H₁₅N₅O₂ 
• 1310448-47-5 3-[(phenylcarbonyl)amino]-4,5-dihydro-1H-pyrazolo[4,3-g]indolizine-8-carboxylic acid 
• 1338562-28-9 2-benzyl-N-hydroxy-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxamide 
• 1338563-21-5 ethyl 2-benzyl-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxylate 
• 2818-07-7 pyrrole-2,4-dicarboxylic acid dimethyl ester 
• 79265-57-9 Pyrrolidine-2,4-dicarboxylic acid diethyl ester 
• 869067-01-6 4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester 
• 903129-94-2 ethyl 4-chloropyrrolo[2,1-f][1,2,4]triazine-6-carboxylate 
• 1338562-78-9 2-(cyclohexylcarbonyl)-N-hydroxy-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxamide 
• 1338562-54-1 N-hydroxy-2-(4-methoxybenzoyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxamide 
• 1338562-37-0 2-(biphenyl-4-ylcarbonyl)-N-hydroxy-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxamide 
• 937-26-8 pyrrole-2,4-dicarboxylic acid 

Relevant articles and documents

2,7,12,17-Tetra(2,5-thienylene)-substituted porphycenes

We report syntheses of thiophene and dithiophene-substituted porphycenes (ThPc and DThPc) at 2,7,12,17-positions by McMurry coupling. The crystal structure of ThPc revealed that the porphycene plane shows a highly planar structure, and the dihedral angles between the porphycene core and thiophene are relatively small at 21deg and 18deg. ThPc and DThPc exhibit red-shifted and broadened absorption because of the extension of I conjugations through porphycene to the substituted thiophenes. We found that introduction of thiophene units onto porphycene results in decreasing the HOMO-LUMO differences effectively.

ROCK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF

The invention relates to a ROCK inhibitor represented by formula (I), its preparation method and its use. The ROCK inhibitor has excellent ROCK inhibition activity, in particular good selective inhibition on ROCK2 kinase, has good safety and metabolic stability, and has high bioavailability. The process of preparing the ROCK inhibitor is simple, and the ROCK inhibitor is easy to purify, and therefore offers good prospects for application.

SUBSTITUTED PYRROLO TRIAZINE CARBOXAMIDE DERIVATIVES AS PROSTAGLANDIN EP3 RECEPTOR ANTAGONISTS

The invention relates to substituted pyrrole triazine carboxamide derivatives of formula (I) and to processes for their preparation, and also /to their use for preparing medicaments for the treatment and/ or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and diabetes, and also urogenital and ophthalmic disorders.