3(2H)-Isoxazolone, 2-methyl-5-phenyl-

Base Information

• Chemical Name: 3(2H)-Isoxazolone, 2-methyl-5-phenyl-
• CAS No.: 942-64-3
• Molecular Formula: C10H9NO2
• Molecular Weight: 175.187
• Mol file: 942-64-3.mol

Synonyms:2-Methyl-5-phenylisoxazol-3(2H)-one;2-Methyl-5-phenyl-4-isoxazolin-3-one;4-Isoxazolin-3-one, 2-methyl-5-phenyl-;

Chemical Property of 3(2H)-Isoxazolone, 2-methyl-5-phenyl-

Chemical Property:

• Melting Point: 114 °C
• Boiling Point: 274.2±43.0 °C (760 mmHg)
• PSA: 35.14000
• Density: 1.226±0.06 g/cm3 (20 °C, 760 mmHg)
• LogP: 1.64530

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3(2H)-Isoxazolone, 2-methyl-5-phenyl-

There total 3 articles about 3(2H)-Isoxazolone, 2-methyl-5-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 3-hydroxy-5-phenylisoxazole (939-05-9) → 3-methoxy-5-phenylisoxazole (942-68-7) + 2-methyl-5-phenyl-isoxazol-3-one (942-64-3)

Guidance literature:

In methanol;

DOI:10.1021/jm00129a016

Reference yield:

3-chloro-2-methyl-5-phenylisoxazolium chloride (66181-90-6) → 2-methyl-5-phenyl-isoxazol-3-one (942-64-3)

Guidance literature:

With 2,3-dinitrophenol; triethylamine; In xylene; for 5h; Heating;

Reference yield:

→ 2-methyl-5-phenyl-isoxazol-3-one (942-64-3)

Guidance literature:

3-Hydroxy-5-phenylisoxazol(2a);

DOI:10.1139/v70-226

upstream raw materials:

3-chloro-2-methyl-5-phenylisoxazolium chloride

diazomethane

3-hydroxy-5-phenylisoxazole

Downstream raw materials:

3-hydroxy-3-phenyl propionic acid N-methyl amide

3-chloro-2-methyl-5-phenylisoxazolium chloride

2-methyl-5-phenyl-4-isoxazolin-3-thione

3-chloro-5-phenylisoxazole