2-Chloro-4'-fluorochalcone

Base Information

Chemical Name:2-Chloro-4'-fluorochalcone
CAS No.:28081-11-0
Molecular Formula:C15H10 Cl F O
Molecular Weight:260.695
Hs Code.:2914700090
European Community (EC) Number:654-182-7
NSC Number:201848
DSSTox Substance ID:DTXSID00419456
Nikkaji Number:J1.746.158C
Wikidata:Q76306095
Mol file:28081-11-0.mol

Synonyms:2-chloro-4'-fluorochalcone;28081-11-0;(E)-3-(2-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one;NSC201848;3-(2-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one;DTXSID00419456;MFCD00018312;AKOS001325039;NSC-201848;A819321;Z46048764;(E)-3-(2-chlorophenyl)-1-(4-fluorophenyl)-2-propen-1-one

Suppliers and Price of 2-Chloro-4'-fluorochalcone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Chloro-4''-fluorochalcone
50mg
$ 45.00

Sigma-Aldrich
2-CHLORO-4'-FLUOROCHALCONE Aldrich
1g
$ 144.00

American Custom Chemicals Corporation
2-CHLORO-4'-FLUOROCHALCONE 95.00%
5MG
$ 497.30

AHH
2-Chloro-4'-fluorochalcone 98%
250g
$ 529.00

Total 12 raw suppliers

Chemical Property of 2-Chloro-4'-fluorochalcone

Chemical Property:

Melting Point:86-90 °C
Boiling Point:389.6°Cat760mmHg
Flash Point:189.4°C
PSA：17.07000
Density:1.265g/cm³
LogP:4.37520
XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:260.0404208
Heavy Atom Count:18
Complexity:308

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-4''-fluorochalcone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 38
Safety Statements: 37

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C=CC(=O)C2=CC=C(C=C2)F)Cl
Isomeric SMILES:C1=CC=C(C(=C1)/C=C/C(=O)C2=CC=C(C=C2)F)Cl

Technology Process of 2-Chloro-4'-fluorochalcone

There total 2 articles about 2-Chloro-4'-fluorochalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.7%

: 89-98-5
2-chloro-benzaldehyde

: 403-42-9
1-(4-fluorophenyl)ethanone

: 28081-11-0
3-(2-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one

Guidance literature:: With sodium hydroxide; In ethanol; water; at 20 ℃; Cooling with ice;
DOI:10.1016/j.bioorg.2020.104527

Reference yield:

: 28081-11-0
3-(2-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one

Guidance literature:: p-Fluor-acetophenon, o-Chlor-benzaldehyd;

Reference yield: 92.0%

: 1117-19-7
dipropyl malonate

: 28081-11-0
3-(2-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one

: 1012919-06-0
dipropyl 2-(1-(2-chlorophenyl)-3-(4-fluorophenyl)-3-oxopropyl)malonate

Guidance literature:: With (1R,2R)-1,2-diphenylethane-1,2-bis(2,5-dimethylphenyl)sulfonamide; strontium bis; In toluene; at 25 ℃; for 7h; optical yield given as %ee; enantioselective reaction;
DOI:10.1246/cl.2009.296