(4-(phenylsulfonyl)phenyl)MethanaMine

Base Information

• Chemical Name: (4-(phenylsulfonyl)phenyl)MethanaMine
• CAS No.: 94341-56-7
• Molecular Formula: C13H13NO2S
• Molecular Weight: 247.318
• Hs Code.: 2921499090
• Mol file: 94341-56-7.mol

Synonyms:4-Phenylsulfon-benzylamin;4-benzenesulfonylbenzylamine;4-Benzolsulfonyl-benzylamin;QC-173;

Chemical Property of (4-(phenylsulfonyl)phenyl)MethanaMine

Chemical Property:

• Boiling Point: 437.0±28.0 °C(Predicted)
• PKA: 8.45±0.10(Predicted)
• PSA: 68.54000
• Density: 1.250±0.06 g/cm3(Predicted)
• LogP: 3.75920
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%Min ^*data from raw suppliers

4-Benzenesulfonyl-benzylamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-(phenylsulfonyl)phenyl)MethanaMine

There total 14 articles about (4-(phenylsulfonyl)phenyl)MethanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-(4-benzenesulfonyl-benzyl)-phthalimide (102467-02-7) → [4-(benzenesulfonyl)phenyl]methanamine (94341-56-7)

Guidance literature:

N-(4-benzenesulfonyl-benzyl)-phthalimide; With hydrazine; In ethanol; for 3h; Heating / reflux;

With sodium hydroxide; In water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield: 71.0%

1-Azidomethyl-4-benzenesulfonyl-benzene → [4-(benzenesulfonyl)phenyl]methanamine (94341-56-7)

Guidance literature:

With sodium hydrogen telluride; In diethyl ether; ethanol; for 0.25h; Ambient temperature;

DOI:10.1246/cl.1984.1733

Reference yield:

4-(phenylsulfonyl)benzonitrile (28525-13-5) → [4-(benzenesulfonyl)phenyl]methanamine (94341-56-7)

Guidance literature:

With methanol; ammonia; nickel; Hydrogenation;

DOI:10.1039/jr9480000381

upstream raw materials:

4-(phenylsulfonyl)benzonitrile

N-(4-benzenesulfonyl-benzyl)-phthalimide

4-benzenesulfonyl-benzaldehyde-oxime

benzenesulfonamide

Downstream raw materials:

4-Amino-6-chloro-5-cyano-pyridine-2-carboxylic acid 4-benzenesulfonyl-benzylamide

2-cyano-1-(imidazo[1,2-a]pyridin-7-yl)-3-(4-(phenylsulfonyl)benzyl)guanidine

2-cyano-1-(imidazo[1,2-a]pyridin-7-ylmethyl)-3-(4-(phenylsulfonyl)benzyl)guanidine

C₂₁H₁₉N₃O₃S

Refernces

• 1、 Zheng, Xiaozhang,Baumeister, Timm,Buckmelter, Alexandre J.,Caligiuri, Maureen,Clodfelter, Karl H.,Han, Bingsong,Ho, Yen-Ching,Kley, Nikolai,Lin, Jian,Reynolds, Dominic J.,Sharma, Geeta,Smith, Chase C.,Wang, Zhongguo,Dragovich, Peter S.,Oh, Angela,Wang, Weiru,Zak, Mark,Wang, Yunli,Yuen, Po-Wai,Bair, Kenneth W.. "Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors". . p. 337 - 343. Retrieved 2015/03/18.
• 2、 -. "AMIDO-BENZYL SULFONE AND SULFONAMIDE DERIVATIVES". Page/Page column 74. . Retrieved 2013/09/12.