Technology Process of Methanone,
[3-(aminomethyl)-4-hydroxyphenyl][6,7-dichloro-2,3-dihydro-2-(hydroxy
methyl)-5-benzofuranyl]-, hydrochloride
There total 7 articles about Methanone,
[3-(aminomethyl)-4-hydroxyphenyl][6,7-dichloro-2,3-dihydro-2-(hydroxy
methyl)-5-benzofuranyl]-, hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; hydrogen;
palladium on activated charcoal;
In
ethanol;
for 1h;
DOI:10.1021/jm50001a009
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 97 percent / conc. H2SO4 / 24 h / Ambient temperature
2: 54 percent / conc. H2SO4 / 6 h / 10 - 15 °C
3: 58 percent / conc. aq. HCl / ethanol / 4 h / Heating
4: 92 percent / aq. KHCO3 / acetonitrile / 1.5 h
5: 54 percent / NaBH4 / ethanol / 2.5 h / 5 - 10 °C
6: 69 percent / H2, conc. aq. HCl / 5percent Pd/C / ethanol / 1 h
With
hydrogenchloride; sodium tetrahydroborate; sulfuric acid; hydrogen; potassium hydrogencarbonate;
palladium on activated charcoal;
In
ethanol; acetonitrile;
DOI:10.1021/jm50001a009
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 73 percent / acetaldoxime, NaOH / dimethylformamide / Ambient temperature
2: 97 percent / conc. H2SO4 / 24 h / Ambient temperature
3: 54 percent / conc. H2SO4 / 6 h / 10 - 15 °C
4: 58 percent / conc. aq. HCl / ethanol / 4 h / Heating
5: 92 percent / aq. KHCO3 / acetonitrile / 1.5 h
6: 54 percent / NaBH4 / ethanol / 2.5 h / 5 - 10 °C
7: 69 percent / H2, conc. aq. HCl / 5percent Pd/C / ethanol / 1 h
With
hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; Acetaldehyde oxime; sulfuric acid; hydrogen; potassium hydrogencarbonate;
palladium on activated charcoal;
In
ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm50001a009
