90246-55-2Relevant academic research and scientific papers
[(Aminomethyl)aryloxy]acetic acid esters. A new class of high-ceiling diuretics. 4. Substituted 6,7-dichloro-2,3-dihydrobenzofurans derived by ring annelation.
Lee,Parks,Bunnell,Plattner,Field,Giebisch
, p. 589 - 594 (2007/10/02)
Ring annelation of the [(aminomethyl)aryloxy]acetic acids produced a series of substituted 6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acids. Pharmacologic evaluation of these compounds in rats and dogs indicated that several congeners are extremely p
acetic Acid Esters. A New Class of High-Ceiling Diuretics. 2. Modifications of the Oxyacetic Side Chain
Plattner, Jacob J.,Fung, Anthony K.L.,Smital, Jill R.,Lee, Cheuk-Man,Crowley, Steven R.,et al.
, p. 1587 - 1596 (2007/10/02)
The discovery of high-ceiling natriuretic activity from a series of aminomethyl derivatives of ethyl acetate prompted our continued investigation of this new class of (aryloxy)acetic acid diuretics.Systematic alte
Substituted 5,6-dihydrofuro[3,2-f]-1,2-benzisoxazole-6-carboxylic acids: High-ceiling diuretics with uricosuric activity
Plattner,Fung,Parks,et al.
, p. 1016 - 1026 (2007/10/02)
A series of substituted 5,6-dihydrofuro[3,2-f]-1,2-benzisoxazoles was prepared and evaluated for their saluretic and uricosuric properties. Pharmacological evaluation of the title compounds was carried out in mice, rats, dogs, and monkeys. The diuretic/sa
Benzisoxazole carboxylic acids
-
, (2008/06/13)
Described are compounds of the formula STR1 wherein X is hydrogen, loweralkyl, halo, loweralkoxy or trifluoromethyl, and Z is hydrogen, loweralkyl, halo, hydroxy or alkoxy, or compounds of the formula STR2 wherein X' and Y' may be the same or different an
Benzisoxazole carboxylic acids
-
, (2008/06/13)
Described are compounds of the formula STR1 wherein X is hydrogen, loweralkyl, halo, loweralkoxy or trifluoromethyl, and Z is hydrogen, loweralkyl, halo, hydroxy or alkoxy, or compounds of the formula STR2 wherein X' and Y' may be the same or different an
