6-Chloro-4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol

Base Information

Chemical Name:6-Chloro-4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
CAS No.:15741-67-0
Molecular Formula:C₈H₁₀ClNO₃
Molecular Weight:203.625
Hs Code.:
NSC Number:166898
DSSTox Substance ID:DTXSID40304711
Wikidata:Q82050847
Mol file:15741-67-0.mol

Synonyms:15741-67-0;NSC166898;6-chloro-4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol;DTXSID40304711;NSC-166898

Suppliers and Price of 6-Chloro-4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 6-Chloro-4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol

Chemical Property:

Vapor Pressure:1.57E-11mmHg at 25°C
Boiling Point:517.4°Cat760mmHg
Flash Point:266.7°C
Density:1.486g/cm³
XLogP3:0.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:203.0349209
Heavy Atom Count:13
Complexity:170

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=C(C(=N1)Cl)CO)CO)O

Technology Process of 6-Chloro-4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol

There total 8 articles about 6-Chloro-4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18724-73-7
methyl 3-cyano-2-hydroxy-6-methyl-isonicotinate

: 15741-67-0
2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)-6-chlorpyridine

Guidance literature:: Multi-step reaction with 6 steps

1: urea; acetic acid anhydride; HNO₃

2: chlorobenzene; PCl₅

3: iron; acetic acid

4: platinum; aqueous HCl / Hydrogenation

5: H₂O; aqueous NaNO₂ / 70 °C

6: aluminium chloride; sodium borate; dimethyl ether

With hydrogenchloride; sodium borate; aluminium trichloride; Dimethyl ether; phosphorus pentachloride; water; nitric acid; acetic anhydride; iron; acetic acid; chlorobenzene; urea; platinum; sodium nitrite;
DOI:10.1021/ja01556a021

Reference yield:

: 98590-00-2
3-cyano-2-hydroxy-6-methyl-5-nitro-isonicotinic acid methyl ester

: 15741-67-0
2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)-6-chlorpyridine

Guidance literature:: Multi-step reaction with 5 steps

1: chlorobenzene; PCl₅

2: iron; acetic acid

3: platinum; aqueous HCl / Hydrogenation

4: H₂O; aqueous NaNO₂ / 70 °C

5: aluminium chloride; sodium borate; dimethyl ether

With hydrogenchloride; sodium borate; aluminium trichloride; Dimethyl ether; phosphorus pentachloride; water; iron; acetic acid; chlorobenzene; platinum; sodium nitrite;
DOI:10.1021/ja01556a021

Reference yield:

: 100313-76-6
2-chloro-3-cyano-6-methyl-5-nitro-isonicotinic acid methyl ester

: 15741-67-0
2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)-6-chlorpyridine

Guidance literature:: Multi-step reaction with 4 steps

1: iron; acetic acid

2: platinum; aqueous HCl / Hydrogenation

3: H₂O; aqueous NaNO₂ / 70 °C

4: aluminium chloride; sodium borate; dimethyl ether

With hydrogenchloride; sodium borate; aluminium trichloride; Dimethyl ether; water; iron; acetic acid; platinum; sodium nitrite;
DOI:10.1021/ja01556a021