Phosphinic acid, (hydroxyphenylmethyl)phenyl-, ethyl ester

Base Information

• Chemical Name: Phosphinic acid, (hydroxyphenylmethyl)phenyl-, ethyl ester
• CAS No.: 96108-74-6
• Molecular Formula: C15H17O3P
• Molecular Weight: 276.272
• DSSTox Substance ID: DTXSID50387752
• Nikkaji Number: J763.254A
• ChEMBL ID: CHEMBL1573059
• Mol file: 96108-74-6.mol

Synonyms:[ethoxy(phenyl)phosphoryl]-phenylmethanol;Phosphinic acid, (hydroxyphenylmethyl)phenyl-, ethyl ester;96108-74-6;Oprea1_264974;MLS000679055;CHEMBL1573059;DTXSID50387752;HMS2567E17;SMR000269989;ethyl [hydroxy(phenyl)methyl]phenylphosphinate;AB00113630-01;SR-01000499554;SR-01000499554-1;Phenyl(alpha-hydroxybenzyl)phosphinic acid ethyl ester

Chemical Property of Phosphinic acid, (hydroxyphenylmethyl)phenyl-, ethyl ester

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 276.09153140
• Heavy Atom Count: 19
• Complexity: 307

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOP(=O)(C1=CC=CC=C1)C(C2=CC=CC=C2)O

Technology Process of Phosphinic acid, (hydroxyphenylmethyl)phenyl-, ethyl ester

There total 3 articles about Phosphinic acid, (hydroxyphenylmethyl)phenyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl hydrogen phenylphosphonate (4546-19-4) + benzaldehyde (100-52-7) → O-ethyl-(1-hydroxy-1-phenylmethyl)-phenylphosphinate (96108-74-6)

Guidance literature:

With triethylamine; at 65 - 70 ℃; for 1h;

Reference yield: 84.0%

ethyl Phenylphosphinate (172487-18-2,2511-09-3) + benzaldehyde (100-52-7) → O-ethyl-(1-hydroxy-1-phenylmethyl)-phenylphosphinate (96108-74-6)

Guidance literature:

With aluminum oxide; potassium fluoride; Ambient temperature;

DOI:10.1039/p19960002179

Reference yield:

→ O-ethyl-(1-hydroxy-1-phenylmethyl)-phenylphosphinate (96108-74-6)

Guidance literature:

/BRN= 3155964/;

upstream raw materials:

ethyl hydrogen phenylphosphonate

benzaldehyde

ethyl Phenylphosphinate

Downstream raw materials:

ethyl 1-butyryloxy-1-phenylmethane(P-phenyl)phosphinate

ethyl (R_P,S)-hydroxy(phenyl)methane(P-phenyl)phosphinate

Ethyl α-aminobenzyl(phenyl)phosphinate