Benzenebutanoic acid, 2,4-dimethoxy-

Base Information

• Chemical Name: Benzenebutanoic acid, 2,4-dimethoxy-
• CAS No.: 96818-18-7
• Molecular Formula: C12H16O4
• Molecular Weight: 224.257
• Mol file: 96818-18-7.mol

Synonyms:

Chemical Property of Benzenebutanoic acid, 2,4-dimethoxy-

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenebutanoic acid, 2,4-dimethoxy-

There total 5 articles about Benzenebutanoic acid, 2,4-dimethoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(E)-4-(3’,5’-dimethoxyphenyl)but-3-enoic acid (51114-95-5) → 4-(3,5-dimethoxyphenyl)butanoic acid (96818-18-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; ethyl acetate; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02851

Reference yield: 86.0%

3-(2',4'-dimethoxybenzoyl)propionic acid (14617-06-2) → 4-(3,5-dimethoxyphenyl)butanoic acid (96818-18-7)

Guidance literature:

With triethylsilane; trifluoroacetic acid; at 0 - 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02039

Reference yield: 86.0%

succinic acid anhydride (108-30-5) + 1,3-Dimethoxybenzene (151-10-0) → 4-(3,5-dimethoxyphenyl)butanoic acid (96818-18-7)

Guidance literature:

succinic acid anhydride; 1,3-Dimethoxybenzene; With aluminum (III) chloride; In dichloromethane; at 0 - 20 ℃; for 15h; Inert atmosphere;

With triethylsilane; trifluoroacetic acid; at 0 - 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.joc.8b00802

upstream raw materials:

3-(2',4'-dimethoxybenzoyl)propionic acid

1,3-Dimethoxybenzene

(E)-4-(3’,5’-dimethoxyphenyl)but-3-enoic acid

3,5-dimethoxybenzaldehdye

Downstream raw materials:

5-(2,4-dimethoxy-phenyl)-pentan-2-ol

4-(2,4-dimethoxy-phenyl)-butan-1-ol

4-(5-bromo-2,4-dimethoxy-phenyl)-butyric acid

1-(2,4-dimethoxy-phenyl)-4-(toluene-4-sulfonyloxy)-pentane