(4-Methoxyphenyl)(5-phenyl-1,3-oxazol-2-yl)methanone

Base Information

Chemical Name:(4-Methoxyphenyl)(5-phenyl-1,3-oxazol-2-yl)methanone
CAS No.:96829-91-3
Molecular Formula:C17H13NO3
Molecular Weight:279.295
Hs Code.:
DSSTox Substance ID:DTXSID10537958
Wikidata:Q82413145

Synonyms:(4-methoxyphenyl)(5-phenyl-1,3-oxazol-2-yl)methanone;96829-91-3;DTXSID10537958;(4-methoxyphenyl)-(5-phenyl-oxazol-2-yl)-methanone

Suppliers and Price of (4-Methoxyphenyl)(5-phenyl-1,3-oxazol-2-yl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of (4-Methoxyphenyl)(5-phenyl-1,3-oxazol-2-yl)methanone

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:279.08954328
Heavy Atom Count:21
Complexity:346

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C(=O)C2=NC=C(O2)C3=CC=CC=C3

Technology Process of (4-Methoxyphenyl)(5-phenyl-1,3-oxazol-2-yl)methanone

There total 6 articles about (4-Methoxyphenyl)(5-phenyl-1,3-oxazol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1006-68-4
5-phenyloxazole

: 701-53-1
p-methoxybenzoyl fluoride

: 96829-91-3
(4-methoxyphenyl)(5-phenyloxazol-2-yl)methanone

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triphenylphosphine; copper(l) chloride; In toluene; at 80 ℃; for 24h; Inert atmosphere;
DOI:10.1021/acs.orglett.0c02603

Reference yield: 65.0%

: 20662-89-9
4-phenyl-1,3-oxazole

: 201230-82-2
carbon monoxide

: 696-62-8
para-iodoanisole

: 96829-91-3
(4-methoxyphenyl)(5-phenyloxazol-2-yl)methanone

Guidance literature:: With copper(l) iodide; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; 1,3-bis-(diphenylphosphino)propane; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 - 130 ℃; under 30003 Torr; Inert atmosphere; Autoclave;
DOI:10.1002/anie.201003895

Reference yield:

: 121-97-1
4-Methoxypropiophenone

: 96829-91-3
(4-methoxyphenyl)(5-phenyloxazol-2-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: n-Butyl nitrite; hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

2: diethylamino-sulfur trifluoride / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; copper(l) chloride; potassium carbonate / toluene / 24 h / 80 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-Butyl nitrite; diethylamino-sulfur trifluoride; potassium carbonate; triphenylphosphine; copper(l) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;
DOI:10.1021/acs.orglett.0c02603