1,2-dihexanoyl-sn-glycero-3-phosphoethanolaMine

Base Information

• Chemical Name: 1,2-dihexanoyl-sn-glycero-3-phosphoethanolaMine
• CAS No.: 96893-06-0
• Molecular Formula: C₁₇H₃₄NO₈P
• Molecular Weight: 411.433
• Mol file: 96893-06-0.mol

Synonyms:1,2-Dihexanoyl-sn-glycero-phosphoethanolamine;Hexanoic acid, 1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester, (R)-;Hexanoic acid, (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester;

Chemical Property of 1,2-dihexanoyl-sn-glycero-3-phosphoethanolaMine

Chemical Property:

• Boiling Point: 518.0±60.0 °C (760 mmHg)
• PSA: 144.19000
• Density: 1.160±0.06 g/cm3(20 °C , 760mmHg)
• LogP: 3.39460

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,2-Dihexanoyl-sn-glycero-phosphoethanolamine s used as drug dosage form of phenylcarbamoylaminobenzoates for enhancing cell survival rate.

Technology Process of 1,2-dihexanoyl-sn-glycero-3-phosphoethanolaMine

There total 9 articles about 1,2-dihexanoyl-sn-glycero-3-phosphoethanolaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

O-(1,2-O-di-hexanoyl-sn-3-glyceryl) O-<2'-((N-tert-butyloxycarbonyl)amino)ethyl> O-(2''-(trimethylsilyl)-ethyl) phosphate (160531-64-6) → 1,2-O-di-hexanoyl-sn-3-glycero-3-phosphothanolamine (96893-06-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; 0 deg C, 30 min; 0 deg C - r.t.;

DOI:10.1021/jo00096a023

Reference yield: 75.0%

2-<(benzyloxycarbonyl)amino>ethyl (2R)-1,2-bis(hexanoyloxy)-1-propyl phenyl phosphate (161510-91-4) → 1,2-O-di-hexanoyl-sn-3-glycero-3-phosphothanolamine (96893-06-0)

Guidance literature:

With hydrogen; acetic acid; platinum(IV) oxide; palladium on activated charcoal; In isopropyl alcohol;

DOI:10.1021/jm00050a009

Reference yield:

1,2-dihexanoyl-sn-glycerol (30403-47-5,75685-80-2) → 1,2-O-di-hexanoyl-sn-3-glycero-3-phosphothanolamine (96893-06-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) N,N-diisopropylethylamine / 1.) THF, -78 deg C, 15 min, 2.) THF, a) -78 deg C, 1 h, b) 25 deg C, 14 h

2: 30percent H₂O₂ / CH₂Cl₂

3: 75 percent / H₂, AcOH / PtO₂, 10percent Pd/C / propan-2-ol

With hydrogen; dihydrogen peroxide; acetic acid; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; palladium on activated charcoal; In dichloromethane; isopropyl alcohol;

DOI:10.1021/jm00050a009

upstream raw materials:

O-(1,2-O-di-hexanoyl-sn-3-glyceryl) O-<2'-((N-tert-butyloxycarbonyl)amino)ethyl> O-(2''-(trimethylsilyl)-ethyl) phosphate

2-<(benzyloxycarbonyl)amino>ethyl (2R)-1,2-bis(hexanoyloxy)-1-propyl phenyl phosphate

1,2-dihexanoyl-sn-glycerol

benzyl (2S)-2,3-bis(hexanoyloxy)-1-propyl ether