1,2-DIHEXANOYL-SN-GLYCEROL

Base Information

• Chemical Name: 1,2-DIHEXANOYL-SN-GLYCEROL
• CAS No.: 30403-47-5
• Molecular Formula: C15H28O5
• Molecular Weight: 288.384
• Hs Code.: 2917190090
• Mol file: 30403-47-5.mol

Synonyms:1,2-DIHEXANOYL-SN-GLYCEROL;1,2-DIHEXANOYL-SN-GLYCEROL (C6:0);1,2-DIHEXANOYL-SN-GLYCEROL (C6:3);glyceryl 1,2-dihexanoate

Chemical Property of 1,2-DIHEXANOYL-SN-GLYCEROL

Chemical Property:

• PSA: 72.83000
• LogP: 2.59430

Purity/Quality:

HPLC>98% ^*data from raw suppliers

1,2-Dihexanoyl-sn-glycerol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,2-Dihexanoyl-sn-glycerol functions as bioregulators of protein kinase C (PKC) in human platelets.

Technology Process of 1,2-DIHEXANOYL-SN-GLYCEROL

There total 7 articles about 1,2-DIHEXANOYL-SN-GLYCEROL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

benzyl (2S)-2,3-bis(hexanoyloxy)-1-propyl ether (108609-67-2) → 1,2-dihexanoyl-sn-glycerol (30403-47-5,75685-80-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; acetic acid; Ambient temperature;

DOI:10.1021/jo00096a023

Reference yield:

Hexanoyl chloride (142-61-0) → 1,2-dihexanoyl-sn-glycerol (30403-47-5,75685-80-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 6 h / 25 °C

2: 85 percent / AcOH, H₂ / 10percent Pd/C / propan-2-ol / 18 h / 2585.7 Torr

With dmap; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In dichloromethane; isopropyl alcohol;

DOI:10.1021/jm00050a009

Reference yield:

hexanoic acid (142-62-1) → 1,2-dihexanoyl-sn-glycerol (30403-47-5,75685-80-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / DCC, DMAP / CH₂Cl₂ / 10 h / Ambient temperature

2: 87 percent / H₂ / 10percent Pd/C / ethanol; acetic acid / Ambient temperature

With dmap; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid;

DOI:10.1021/jo00096a023

upstream raw materials:

benzyl (2S)-2,3-bis(hexanoyloxy)-1-propyl ether

hexanoic acid, 1,2,3-propanetriyl ester

1,2-di-O-hexanoyl-3-O-p-methoxybenzyl-sn-glycerol

Hexanoyl chloride

Downstream raw materials:

Hexanoic acid (R)-1-hexanoyloxymethyl-2-[((1R,2R,3S,4R,5S)-2,3,4,5-tetrakis-benzyloxy-cyclohexyloxy)-(2-trimethylsilanyl-ethoxy)-phosphanyloxy]-ethyl ester

Hexanoic acid (R)-1-hexanoyloxymethyl-2-[((1S,2R,3S,4S,5R,6S)-2,3,4,5-tetrakis-benzyloxy-6-fluoro-cyclohexyloxy)-(2-trimethylsilanyl-ethoxy)-phosphanyloxy]-ethyl ester

Hexanoic acid (R)-1-hexanoyloxymethyl-2-(methoxy-phenoxy-phosphanyloxy)-ethyl ester

(S)-2-[((R)-2,3-Bis-hexanoyloxy-propoxy)-phenoxy-phosphanyloxymethyl]-pyrrolidine-1-carboxylic acid benzyl ester