N-(6-Amino-2-oxo-2H-1-benzopyran-3-yl)acetamide

Base Information

• Chemical Name: N-(6-Amino-2-oxo-2H-1-benzopyran-3-yl)acetamide
• CAS No.: 97126-20-0
• Molecular Formula: C11H10N2O3
• Molecular Weight: 218.20900
• Hs Code.: 2932209090
• Mol file: 97126-20-0.mol

Synonyms:Acetamide,N-(6-amino-2-oxo-2H-1-benzopyran-3-yl);3-acetamido-6-aminochromen-2-one;N-(6-Amino-2-oxo-2H-chromen-3-yl)acetamide;

Chemical Property of N-(6-Amino-2-oxo-2H-1-benzopyran-3-yl)acetamide

Chemical Property:

• PSA: 88.82000
• LogP: 2.56430

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(6-Amino-2-oxo-2H-1-benzopyran-3-yl)acetamide

There total 3 articles about N-(6-Amino-2-oxo-2H-1-benzopyran-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3-acetamido-6-nitro-2H-chromen-2-one (787-63-3) → 3-acetamido-6-aminochromen-2-one (97126-20-0)

Guidance literature:

With sodium tetrahydroborate; palladium on activated charcoal; In methanol; water; for 0.25h;

DOI:10.1002/jhet.5570230118

Reference yield:

5-Nitrosalicylaldehyde (97-51-8) → 3-acetamido-6-aminochromen-2-one (97126-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / NaH; Ac₂O / 20 h / 20 °C

2: 57 percent / aq. NaBH₄ / Pd/C / methanol / 0.5 h / 20 °C

With sodium tetrahydroborate; acetic anhydride; sodium hydride; palladium on activated charcoal; In methanol;

DOI:10.1021/ja045742x

Reference yield:

3-acetamido-6-nitro-2H-chromen-2-one (787-63-3) + pyrographite (7440-44-0) + palladium (7440-05-3) → 3-acetamido-6-aminochromen-2-one (97126-20-0)

Guidance literature:

With sodium borohydrid; In methanol; water;

upstream raw materials:

3-acetamido-6-nitro-2H-chromen-2-one

pyrographite

palladium

5-Nitrosalicylaldehyde