1,1,3,3-Tetramethyl-2-(1-phenylethoxy)-2,3-dihydro-1H-isoindole

Base Information

Chemical Name:1,1,3,3-Tetramethyl-2-(1-phenylethoxy)-2,3-dihydro-1H-isoindole
CAS No.:97142-01-3
Molecular Formula:C20H25NO
Molecular Weight:295.425
Hs Code.:
DSSTox Substance ID:DTXSID50540542

Synonyms:97142-01-3;DTXSID50540542;1,1,3,3-Tetramethyl-2-(1-phenylethoxy)-2,3-dihydro-1H-isoindole

Suppliers and Price of 1,1,3,3-Tetramethyl-2-(1-phenylethoxy)-2,3-dihydro-1H-isoindole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,1,3,3-Tetramethyl-2-(1-phenylethoxy)-2,3-dihydro-1H-isoindole

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:295.193614421
Heavy Atom Count:22
Complexity:359

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=CC=C1)ON2C(C3=CC=CC=C3C2(C)C)(C)C

Technology Process of 1,1,3,3-Tetramethyl-2-(1-phenylethoxy)-2,3-dihydro-1H-isoindole

There total 8 articles about 1,1,3,3-Tetramethyl-2-(1-phenylethoxy)-2,3-dihydro-1H-isoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 80037-90-7
1,1,3,3-tetramethyl-2,3-dihydro-1H-isoindol-2-yloxoyl radical

: 585-71-7,38661-81-3
(1-bromoethyl)benzne

: 97142-01-3
1-phenyl-1-(1,1,3,3-tetramethylisoindolin-2-yloxy)ethane

Guidance literature:: With N,N,N',N'',N'''-pentamethyldiethylenetriamine; copper(I) bromide; In toluene; at 50 ℃; for 2h; Sealed tube; Inert atmosphere;
DOI:10.1021/jacs.8b03633

Reference yield:

: 2348-51-8
1-phenylethyl radical

: 80037-90-7
1,1,3,3-tetramethyl-2,3-dihydro-1H-isoindol-2-yloxoyl radical

: 97142-01-3
1-phenyl-1-(1,1,3,3-tetramethylisoindolin-2-yloxy)ethane

Guidance literature:: In 2,2,4-trimethylpentane; at 18 ℃; Rate constant;
DOI:10.1021/ja00039a006

Reference yield:

: 80037-90-7
1,1,3,3-tetramethyl-2,3-dihydro-1H-isoindol-2-yloxoyl radical

: 1,1,3,3-tetramethyl-2-(1-xanthon-2-ylethoxy)chromeno[3,2-f]isoindolin-10-one

: 97142-01-3
1-phenyl-1-(1,1,3,3-tetramethylisoindolin-2-yloxy)ethane

Guidance literature:: Multi-step reaction with 4 steps

1: periodic acid; sulfuric acid; potassium iodide / 5 h / 0 - 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / N,N-dimethyl-formamide / 18 h / 130 °C / Sealed tube; Inert atmosphere

3: N,N,N',N'',N'''-pentamethyldiethylenetriamine; copper(I) bromide / toluene / 2 h / 50 °C / Sealed tube; Inert atmosphere

4: benzene-d6 / 5.5 h / 20 °C / Inert atmosphere; UV-irradiation

With bis-triphenylphosphine-palladium(II) chloride; N,N,N',N'',N'''-pentamethyldiethylenetriamine; sulfuric acid; potassium carbonate; periodic acid; potassium iodide; copper(I) bromide; In benzene-d6; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jacs.8b03633