2-Pyridinecarboxylic acid, 6-(bromomethyl)-, ethyl ester

Base Information

• Chemical Name: 2-Pyridinecarboxylic acid, 6-(bromomethyl)-, ethyl ester
• CAS No.: 97278-44-9
• Molecular Formula: C9H10BrNO2
• Molecular Weight: 244.088
• Hs Code.: 2933399090
• Mol file: 97278-44-9.mol

Synonyms:6-bromomethyl-pyridine-2-carboxylic acid ethyl ester;2-Pyridinecarboxylic acid,6-(bromomethyl)-,ethyl ester;Ethyl 6-(bromomethyl)picolinate;2-Bromomethyl-6-pyridine carboxylic acid ethyl ester;ethyl 6-(bromomethyl)-2-pyridinecarboxylate;

Chemical Property of 2-Pyridinecarboxylic acid, 6-(bromomethyl)-, ethyl ester

Chemical Property:

• Boiling Point: 327.5±32.0 °C(Predicted)
• PKA: 0.66±0.10(Predicted)
• PSA: 39.19000
• Density: 1.465±0.06 g/cm3(Predicted)
• LogP: 2.15320
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

95% ^*data from raw suppliers

2-Bromomethyl-6-pyridinecarboxylicacidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridinecarboxylic acid, 6-(bromomethyl)-, ethyl ester

There total 4 articles about 2-Pyridinecarboxylic acid, 6-(bromomethyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

N-Bromosuccinimide (128-08-5) + ethyl 6-methylpyridine-2-carboxylate (39640-51-2) → 6-bromomethylpyridine-2-carboxylic acid ethylester (97278-44-9)

Guidance literature:

In neat (no solvent); for 48h; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1021/om400618n

Reference yield: 32.0%

ethyl 6-methylpyridine-2-carboxylate (39640-51-2) → 6-bromomethylpyridine-2-carboxylic acid ethylester (97278-44-9)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; at 84 ℃; Heating / reflux;

Reference yield:

ethyl 6-(hydroxymethyl)pyridine-2-carboxylate (41337-81-9) → 6-bromomethylpyridine-2-carboxylic acid ethylester (97278-44-9)

Guidance literature:

ethyl 6-(hydroxymethyl)pyridine-2-carboxylate; With phosphorus tribromide; In dichloromethane; at 0 ℃; for 2h;

With sodium hydrogencarbonate; In dichloromethane;

upstream raw materials:

ethyl 6-methylpyridine-2-carboxylate

ethyl 6-(hydroxymethyl)pyridine-2-carboxylate

diethyl-2,6-pyridinedicarbonyl ester

N-Bromosuccinimide

Downstream raw materials:

C₁₅H₁₃Cl₂NO₂S

6-(2-cyanomethoxy-3-formyl-phenoxymethyl)-pyridine-2-carboxylic acid ethyl ester

6-(4-iodo-phenoxymethyl)-pyridine-2-carboxylic acid ethyl ester

Refernces

• 1、 Labbe, Genevieve,Krismanich, Anthony P.,De Groot, Sarah,Rasmusson, Timothy,Shang, Muhong,Brown, Matthew D.R.,Dmitrienko, Gary I.,Guillemette, J. Guy. "Development of metal-chelating inhibitors for the Class II fructose 1,6-bisphosphate (FBP) aldolase". scheme or table. p. 49 - 58. Retrieved 2012/09/21.
• 2、 -. "Inhibitors of 11-beta hydroxysteroid dehydrogenase type I". Page/Page column 29. . Retrieved 2010/11/24.