2-Pentanone, 1-(4-methoxyphenyl)-

Base Information

• Chemical Name: 2-Pentanone, 1-(4-methoxyphenyl)-
• CAS No.: 97968-16-6
• Molecular Formula: C12H16O2
• Molecular Weight: 192.258
• Mol file: 97968-16-6.mol

Synonyms:

Chemical Property of 2-Pentanone, 1-(4-methoxyphenyl)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pentanone, 1-(4-methoxyphenyl)-

There total 12 articles about 2-Pentanone, 1-(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(4-methoxyphenyl)pentane-1,2-dione (33720-27-3) → 1-(4'-methoxyphenyl)-pentan-2-one (97968-16-6)

Guidance literature:

1-(4-methoxyphenyl)pentane-1,2-dione; With sodium iodide; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;

With chloro-trimethyl-silane; In dichloromethane; at 20 ℃; for 22h; regioselective reaction; Inert atmosphere;

DOI:10.1002/adsc.201700276

Reference yield: 88.0%

butanoic acid methyl ester (623-42-7) + 2,2'‐((4‐methoxyphenyl)methylene)bis(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolane) → 1-(4'-methoxyphenyl)-pentan-2-one (97968-16-6)

Guidance literature:

With lithium tert-butoxide; In tetrahydrofuran; at 23 ℃; for 3h; Glovebox;

DOI:10.1021/jacs.9b11944

Reference yield: 85.0%

1-(4-methoxybenzyl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate salt (71017-75-9) + butyraldehyde (123-72-8) → 1-(4'-methoxyphenyl)-pentan-2-one (97968-16-6)

Guidance literature:

1-(4-methoxybenzyl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate salt; With potassium phosphate; (1,2-dimethoxyethane)dichloronickel(II); tetrakis(tetrabutylammonium)decatungstate(VI); 4,4'-di-tert-butyl-2,2'-bipyridine; In acetonitrile; at 25 ℃; for 0.166667h; Inert atmosphere;

butyraldehyde; In acetonitrile; at 25 ℃; for 15h; regioselective reaction; Irradiation; Inert atmosphere;

DOI:10.1021/acs.orglett.1c01716

upstream raw materials:

1-(p-Methoxyphenyl)-2-nitro-penten

1-(4-methoxy-phenyl)-pentane-1,2-diol

n-propylmagnesium bromide

N-methoxy-2-(4-methoxyphenyl)-N-methylethanamide

Downstream raw materials:

C₂₉H₃₁NO₃

C₃₀H₃₃NO₃

C₃₁H₃₅NO₃

1,2,4-tris(4-hydroxyphenyl)-3-methyl-5-propyl-1H-pyrrole

Refernces

• 1、 Murugesan, Vetrivelan,Ganguly, Anirban,Karthika, Ardra,Rasappan, Ramesh. "C-H Alkylation of Aldehydes by Merging TBADT Hydrogen Atom Transfer with Nickel Catalysis". supporting information. p. 5389 - 5393. Retrieved 2021/07/21.
• 2、 Schaefer, Anja,Wellner, Anja,Gust, Ronald. "Synthesis and investigations on the oxidative degradation of C3/C5-Alkyl-1,2,4-triarylpyrroles as ligands for the estrogen receptor". scheme or table. p. 794 - 803. Retrieved 2012/01/06.