Piperazine, 1-(7-benzofuranyl)-

Base Information

• Chemical Name: Piperazine, 1-(7-benzofuranyl)-
• CAS No.: 98224-26-1
• Molecular Formula: C12H14N2O
• Molecular Weight: 202.25200
• DSSTox Substance ID: DTXSID60440347
• Nikkaji Number: J563.724D
• Wikidata: Q82256625
• ChEMBL ID: CHEMBL61032

Synonyms:Piperazine, 1-(7-benzofuranyl)-;98224-26-1;CHEMBL61032;1-(1-benzofuran-7-yl)piperazine;1-(7-benzofuranyl)piperazine;1-Benzofuran-7-yl-piperazine;1-(benzofuran-7-yl)piperazine;SCHEMBL2545146;1-(7-benzo[b]furanyl)piperazine;DTXSID60440347;KFVKNZPFYQDNAE-UHFFFAOYSA-N;BDBM50035042

Chemical Property of Piperazine, 1-(7-benzofuranyl)-

Chemical Property:

• PSA: 28.41000
• LogP: 2.23620
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 202.110613074
• Heavy Atom Count: 15
• Complexity: 216

Purity/Quality:

99% ^*data from raw suppliers

1-(7-benzofuranyl)-Piperazine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CN(CCN1)C2=CC=CC3=C2OC=C3

Technology Process of Piperazine, 1-(7-benzofuranyl)-

There total 4 articles about Piperazine, 1-(7-benzofuranyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(7-benzo[b]furanyl)piperazine-1-carboxylate (187795-32-0) → 1-(7-benzo[b]furanyl)piperazine (98224-26-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; Yield given; Ambient temperature;

DOI:10.1016/S0040-4039(98)00179-8

Reference yield:

1-(benzofuran-7-yl)piperazine hydrochloride (115464-81-8) → 1-(7-benzo[b]furanyl)piperazine (98224-26-1)

Guidance literature:

With sodium hydroxide; In dichloromethane; water;

Reference yield:

bis-(2-chloroethyl)amine hydrochloride (821-48-7) + 7-Amino-benzo[b]furan (67830-55-1) → 1-(7-benzo[b]furanyl)piperazine (98224-26-1)

Guidance literature:

With potassium carbonate; In chlorobenzene; for 24h; Heating;

DOI:10.1021/jm00020a020

upstream raw materials:

bis-(2-chloroethyl)amine hydrochloride

7-Amino-benzo[b]furan

tert-butyl 4-(7-benzo[b]furanyl)piperazine-1-carboxylate

7-bromobenzo(b)furan

Downstream raw materials:

N-<2-<4-(7-benzofuranyl)-1-piperazinyl>ethyl>-4-fluorobenzamide

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