7-Aminobenzofuran

Base Information

• Chemical Name: 7-Aminobenzofuran
• CAS No.: 67830-55-1
• Molecular Formula: C8H7NO
• Molecular Weight: 133.14700
• European Community (EC) Number: 881-496-3

Synonyms:7-AMINOBENZOFURAN;Benzofuran-7-amine;67830-55-1;1-BENZOFURAN-7-AMINE;MFCD11877834;7-BENZOFURANAMINE;7-Amino-benzo[b]furan;SCHEMBL824960;AKOS006222301;MB10414;CS-11903;SY032876;CS-0208630;F20181;EN300-1601155;A867181

Chemical Property of 7-Aminobenzofuran

Chemical Property:

• PSA: 39.16000
• LogP: 2.59620
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 133.052763847
• Heavy Atom Count: 10
• Complexity: 126

Purity/Quality:

98% ^*data from raw suppliers

7-?Aminobenzofuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C(=C1)N)OC=C2
• Uses: 7-?Aminobenzofuran reacted with 4-?chloro-?6-?methoxy-?7-?[3-?(4-?methylpiperazin-?1-?yl)?propoxy]?quinazoline in the presence of HCl/iso-PrOH gave 4-(7-benzofuranylamino)quinazolines with antitumor activity.

Technology Process of 7-Aminobenzofuran

There total 1 articles about 7-Aminobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

nitro-7 benzofuranne (18761-32-5) → 7-Amino-benzo[b]furan (67830-55-1)

Guidance literature:

With hydrazine hydrate; nickel; In methanol; for 0.5h; Heating;

DOI:10.1021/jm030317k

Reference yield:

phenyl (3-methyl-4-phenoxyphenyl)carbamate + 7-Amino-benzo[b]furan (67830-55-1) → 1-(1-benzofuran-7-yl)-3-(3-methyl-4-phenoxyphenyl)urea

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 0 - 100 ℃; for 16h;

Reference yield:

4-chloro-N-[3-(methylsulfonyl)phenyl]-2-pyrimidinamine (945396-93-0) + 7-Amino-benzo[b]furan (67830-55-1) → N'-(benzofuran-7-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine (945396-43-0)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol; at 90 ℃;

DOI:10.1016/j.bmcl.2010.08.100

upstream raw materials:

nitro-7 benzofuranne

Downstream raw materials:

1-(7-benzo[b]furanyl)piperazine

N'-(benzofuran-7-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine

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