Benzyl oxopropyl mesylate

Base Information

• Chemical Name: Benzyl oxopropyl mesylate
• CAS No.: 98518-10-6
• Molecular Formula: C11H16O4S
• Molecular Weight: 244.312
• Mol file: 98518-10-6.mol

Synonyms:3-(benzyloxy)propyl methanesulfonate;benzyloxypropyl mesylate;3-benzyloxy-1-methanesulfonyloxypropane;methanesulfonic acid 3-benzyloxypropyl ester;1-Propanol,3-(phenylmethoxy)-,methanesulfonate;

Chemical Property of Benzyl oxopropyl mesylate

Chemical Property:

• PSA: 92.21000
• LogP: 2.17040

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzyl oxopropyl mesylate

There total 6 articles about Benzyl oxopropyl mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-benzyloxypropan-1-ol (4799-68-2) + methanesulfonyl chloride (124-63-0) → 3-benzyloxy-1-propanol methanesulfonate (98518-10-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1.166h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.9b01287

Reference yield: 89.0%

→ 3-benzyloxy-1-propanol methanesulfonate (98518-10-6)

Guidance literature:

With triethylamine; In tert-butyl methyl ether; at 0 - 20 ℃; for 2h;

Reference yield:

benzyl chloride (100-44-7) → 3-benzyloxy-1-propanol methanesulfonate (98518-10-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / Ambient temperature

2: NEt₃ / CH₂Cl₂ / 0 °C

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(88)90140-7

upstream raw materials:

3-benzyloxypropan-1-ol

methanesulfonyl chloride

2-phenyl-1,3-dioxane

benzaldehyde

Downstream raw materials:

12-(3-benzyloxypropyl)-6H,7H,13H-indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ne

3-(benzyloxy)-N-methylpropan-1-amine

ethyl 2-(3-(benzyloxy)propoxy)acetate