3-Chloro-6-(3-fluoro-4-methoxyphenyl)pyridazine

Base Information

• Chemical Name: 3-Chloro-6-(3-fluoro-4-methoxyphenyl)pyridazine
• CAS No.: 99452-78-5
• Molecular Formula: C11H8ClFN2O
• Molecular Weight: 238.649
• DSSTox Substance ID: DTXSID60606749
• Wikidata: Q82505592

Synonyms:99452-78-5;3-Chloro-6-(3-fluoro-4-methoxyphenyl)pyridazine;3-chloro-6-(3-fluoro-4-methoxyphenyl)-pyridazine;SCHEMBL1742298;DTXSID60606749;XJUAAVLXZBQURX-UHFFFAOYSA-N;3-chloro-6-(4-methoxy-3-fluorophenyl)pyridazine;EN300-1586593;3-Chloro-6-(3-fluoro-4-methoxy-phenyl)-pyridazine

Chemical Property of 3-Chloro-6-(3-fluoro-4-methoxyphenyl)pyridazine

Chemical Property:

• Boiling Point: 414.6±45.0 °C(Predicted)
• PSA: 35.01000
• Density: 1.316±0.06 g/cm3(Predicted)
• LogP: 2.94470
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 238.0309187
• Heavy Atom Count: 16
• Complexity: 232

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C2=NN=C(C=C2)Cl)F

Technology Process of 3-Chloro-6-(3-fluoro-4-methoxyphenyl)pyridazine

There total 1 articles about 3-Chloro-6-(3-fluoro-4-methoxyphenyl)pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,6-dichlorpyridazine (141-30-0) + 3-fluoro-4-methoxy-phenylboronic acid (149507-26-6) → 3-chloro-6-(3-fluoro-4-methoxy-phenyl)-pyridazine (99452-78-5)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 80 ℃; for 16h;

Reference yield:

3-chloro-6-(3-fluoro-4-methoxy-phenyl)-pyridazine (99452-78-5) + phenol (108-95-2,27073-41-2) → 3-(3-fluoro-4-methoxy-phenyl)-6-phenoxy-pyridazine (890021-42-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 0.25h; Microwave irradiation;

Reference yield:

3-chloro-6-(3-fluoro-4-methoxy-phenyl)-pyridazine (99452-78-5) → 6-(3-fluoro-4-methoxyphenyl)-1,2,4-triazolo[4,3-b]pyridazin-3(2H)-one

Guidance literature:

In butan-1-ol;

upstream raw materials:

3,6-dichlorpyridazine

3-fluoro-4-methoxy-phenylboronic acid

Downstream raw materials:

3-(3-fluoro-4-methoxy-phenyl)-6-phenoxy-pyridazine

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