3-(p-Tolyl)cyclohexanone

Base Information

• Chemical Name: 3-(p-Tolyl)cyclohexanone
• CAS No.: 99495-15-5
• Molecular Formula: C13H16O
• Molecular Weight: 188.269
• Mol file: 99495-15-5.mol

Synonyms:3-p-Tolyl-cyclohexanone;3-(p-tolyl)cyclohexanone;3-(4-methylphenyl)cyclohexanone;3-p-tolylcyclohexanone;3-(p-Methylphenyl)cyclohexanone;3-(p-Tolyl)cyclohexan-1-one;3-(4-tolyl)cyclohexanone;

Chemical Property of 3-(p-Tolyl)cyclohexanone

Chemical Property:

• PSA: 17.07000
• LogP: 3.22170

Purity/Quality:

3-(4-Methylphenyl)cyclohexanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(p-Tolyl)cyclohexanone

There total 28 articles about 3-(p-Tolyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cyclohexenone (930-68-7) + 4-methylphenylboronic acid (5720-05-8) → 3-(p-tolyl)cyclohexan-1-one (99495-15-5)

Guidance literature:

With chloroform; caesium carbonate; triphenylphosphine; palladium diacetate; In toluene; at 80 ℃; for 24h;

DOI:10.1246/cl.2006.198

Reference yield: 94.0%

cyclohexenone (930-68-7) + para-methylphenylmagnesium bromide (4294-57-9) → 3-(p-tolyl)cyclohexan-1-one (99495-15-5)

Guidance literature:

para-methylphenylmagnesium bromide; With indium(III) chloride; In tetrahydrofuran; at 20 ℃; for 0.5h;

With water; In tetrahydrofuran; at 20 ℃; for 0.166667h;

cyclohexenone; [Rh(OH)(cod)]2; In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1039/b511779h

Reference yield: 91.0%

cyclohexenone (930-68-7) + (4-methylphenyl)trimethoxysilane (17873-01-7) → 3-(p-tolyl)cyclohexan-1-one (99495-15-5)

Guidance literature:

With tetrakis(actonitrile)copper(I) hexafluorophosphate; water; di(tert-butyl)phosphinous acid-based palladium(II) complex; at 120 ℃; for 4h; microwave irradiation;

DOI:10.1021/ol071067v

upstream raw materials:

cyclohexenone

(4-methylphenyl)azo 4-methylphenyl sulfone

para-chlorotoluene

para-bromotoluene

Downstream raw materials:

cis-1-Methyl-3-(p-tolyl)cyclohexanol

trans-1-Methyl-3-(p-tolyl)cyclohexanol

(R)-3-p-tolyl-cyclohexanone

Refernces

• 1、 Mendoza-Espinosa, Daniel,Rendón-Nava, David,Vásquez-Pérez, Jose M.,Sandoval-Chávez, Cesar I.,Alvarez-Hernández, Alejandro. "Synthesis of multinuclear Rh(I) complexes bearing triazolylidenes and their application in C-C and c-Si bond forming reactions". supporting information. p. 3961 - 3971. Retrieved 2020/12/01.
• 2、 Motokura, Ken,Hashiguchi, Kohei,Maeda, Kyogo,Nambo, Masayuki,Manaka, Yuichi,Chun, Wang-Jae. "Rh-catalyzed 1,4-addition reactions of arylboronic acids accelerated by co-immobilized tertiary amine in silica mesopores". . p. 1 - 9. Retrieved 2019/05/04.