tert-Butyl2,7-diazaspiro[3.5]nonane-7-carboxylatehydrochloride

Base Information

• Chemical Name: tert-Butyl2,7-diazaspiro[3.5]nonane-7-carboxylatehydrochloride
• CAS No.: 1023301-84-9
• Molecular Formula: C12H22N2O2.ClH
• Molecular Weight: 262.78
• Hs Code.: 2933990090
• Mol file: 1023301-84-9.mol

Synonyms:tert-Butyl2,7-diazaspiro[3.5]nonane-7-carboxylatehydrochloride;2,7-Diazaspiro[3.5]nonane-7-carboxylic acid, 1,1-diMethylethyl ester, (Hydrochloride) (1:1)

Chemical Property of tert-Butyl2,7-diazaspiro[3.5]nonane-7-carboxylatehydrochloride

Chemical Property:

• Boiling Point: 319 ?C
• PSA: 58.64000
• LogP: 1.40020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl2,7-Diazaspiro[3.5]nonane-7-carboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl2,7-diazaspiro[3.5]nonane-7-carboxylatehydrochloride

There total 2 articles about tert-Butyl2,7-diazaspiro[3.5]nonane-7-carboxylatehydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

C19H28N2O4S → tert-butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride (1023301-84-9)

Guidance literature:

C₁₉H₂₈N₂O₄S; With magnesium; In methanol; at 20 ℃;

With hydrogenchloride; In deuteromethanol;

Reference yield:

tert-butyl 4-cyano-4-({[(4-methylphenyl)sulfonyl]oxy}methyl)piperidine-1-carboxylate (929302-00-1) → tert-butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride (1023301-84-9)

Guidance literature:

tert-butyl 4-cyano-4-({[(4-methylphenyl)sulfonyl]oxy}methyl)piperidine-1-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

With sodium hydroxide; In tetrahydrofuran; water; for 0.5h;

With hydrogenchloride; In methanol; diethyl ether;

Reference yield: 88.0%

tert-butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride (1023301-84-9) + 4-(aminosulfonyl)-benzoic acid (138-41-0) → 2-(4-sulfamoylbenzoyl)-2,7-diazaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

tert-butyl 4-cyano-4-({[(4-methylphenyl)sulfonyl]oxy}methyl)piperidine-1-carboxylate

Downstream raw materials:

2-(4-methoxyphenyl)-1-{2-[(1R)-5-(pyrimidin-2-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl}ethanone

5-methyl-2-{2-oxo-2-[2-((R)-5-pyrimidin-2-yl-indan-1-yl)-2,7-diaza-spiro[3.5]non-7-yl]ethyl}benzoic acid

5-methyl-2-(2-oxo-2-{2-[(1R)-5-pyrimidin-2-yl-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl}ethyl)benzamide

tert-butyl 2-(5-(2-(benzyloxy)-4-bromo-6-fluorophenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate