tert-butyl 2-(5-(2-(benzyloxy)-4-bromo-6-fluorophenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

Base Information

Chemical Name:tert-butyl 2-(5-(2-(benzyloxy)-4-bromo-6-fluorophenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate
CAS No.:1620516-15-5
Molecular Formula:C₂₇H₃₀BrFN₄O₃S
Molecular Weight:589.529
Hs Code.:

Synonyms:tert-butyl 2-(5-(2-(benzyloxy)-4-bromo-6-fluorophenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

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Chemical Property of tert-butyl 2-(5-(2-(benzyloxy)-4-bromo-6-fluorophenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

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Technology Process of tert-butyl 2-(5-(2-(benzyloxy)-4-bromo-6-fluorophenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

There total 4 articles about tert-butyl 2-(5-(2-(benzyloxy)-4-bromo-6-fluorophenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1023301-84-9
tert-butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride

: 1620516-14-4
2-(2-(benzyloxy)-4-bromo-6-fluorophenyl)-5-bromo-1,3,4-thiadiazole

: 1620516-15-5
tert-butyl 2-(5-(2-(benzyloxy)-4-bromo-6-fluorophenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

Guidance literature:: With triethylamine; In 1,4-dioxane; at 120 ℃; for 3h;

Reference yield:

: 183065-68-1
4-bromo-2,6-difluorobenzoic acid

: 1620516-15-5
tert-butyl 2-(5-(2-(benzyloxy)-4-bromo-6-fluorophenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 3 h / 78 °C / Inert atmosphere; Cooling with ice

2: sodium hydride / tetrahydrofuran; mineral oil / 19 h / 20 - 50 °C / Cooling with ice

3: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 18 h / 20 °C

4: triethylamine / 1,4-dioxane / 3 h / 120 °C

With tert.-butylnitrite; sodium hydride; triethylamine; copper(ll) bromide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; acetonitrile; mineral oil;

Reference yield:

: 1526200-39-4
5-(4-bromo-2,6-difluorophenyl)-1,3,4-thiadiazol-2-amine

: 1620516-15-5
tert-butyl 2-(5-(2-(benzyloxy)-4-bromo-6-fluorophenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 19 h / 20 - 50 °C / Cooling with ice

2: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 18 h / 20 °C

3: triethylamine / 1,4-dioxane / 3 h / 120 °C

With tert.-butylnitrite; sodium hydride; triethylamine; copper(ll) bromide; In tetrahydrofuran; 1,4-dioxane; acetonitrile; mineral oil;