N-isopropylpiperidin-4-amine

Base Information

• Chemical Name: N-isopropylpiperidin-4-amine
• CAS No.: 534595-53-4
• Molecular Formula: C₈H₁₈N₂
• Molecular Weight: 142.244
• Hs Code.: 2933399090
• Mol file: 534595-53-4.mol

Synonyms:4-(isopropylamino)piperidine;Isopropyl(piperidin-4-yl)amine;(ii)-Isopropyl-piperidin-4-yl-amine;N-(propan-2-yl)piperidin-4-amine;N-isopropylpiperidin-4-amine;

Chemical Property of N-isopropylpiperidin-4-amine

Chemical Property:

• Boiling Point: 193.587 °C at 760 mmHg
• PKA: 10.40±0.20(Predicted)
• Flash Point: 67.892 °C
• PSA: 24.06000
• Density: 0.895 g/cm³
• LogP: 1.45610
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

N-Isopropylpiperidin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-isopropylpiperidin-4-amine is used in preparation of 6-substituted benzoxazines as 5-HT5A antagonists for treatment of mental disorders. Intermediate used in preparation of 6-substituted benzoxazines as 5-HT5A antagonists for treatment of mental disorders.

Technology Process of N-isopropylpiperidin-4-amine

There total 1 articles about N-isopropylpiperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-benzyl-4-(1-methylethylamino)piperidine (132442-32-1) → (ii)-Isopropyl-piperidin-4-yl-amine (534595-53-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 18h;

Reference yield:

(ii)-Isopropyl-piperidin-4-yl-amine (534595-53-4) → N-[1-(cyanomethyl-carbamoyl)-cyclohexyl]-4-[2-(4-isopropylamino-piperidin-1-yl)-thiazol-4-yl]-benzamide

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 2 h / 20 - 55 °C

1.2: NH₃ / ethanol; tetrahydrofuran / 20 - 55 °C

2.1: tetrahydrofuran / 3 h / Heating

3.1: Et₃N; HATU / dimethylformamide / 20 °C

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm058198r

Reference yield:

(ii)-Isopropyl-piperidin-4-yl-amine (534595-53-4) → 4-[2-(4-isopropylamino-piperidin-1-yl)-thiazol-4-yl]-benzoic acid

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 2 h / 20 - 55 °C

1.2: NH₃ / ethanol; tetrahydrofuran / 20 - 55 °C

2.1: tetrahydrofuran / 3 h / Heating

In tetrahydrofuran;

DOI:10.1021/jm058198r

upstream raw materials:

1-benzyl-4-(1-methylethylamino)piperidine

Downstream raw materials:

4-isopropylamino-piperidine-1-carbothioic acid amide

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