4-Bromo-6-chloropicolinic acid

Base Information

Chemical Name:4-Bromo-6-chloropicolinic acid
CAS No.:1060805-66-4
Molecular Formula:C6H3BrClNO2
Molecular Weight:236.45100
Hs Code.:2933399090
DSSTox Substance ID:DTXSID70704407
Wikidata:Q72453416
Mol file:1060805-66-4.mol

Synonyms:4-bromo-6-chloropicolinic acid;1060805-66-4;4-bromo-6-chloropyridine-2-carboxylic acid;4-BROMO-6-CHLORO-2-PYRIDINECARBOXYLIC ACID;4-bromo-6-chloropicolinicacid;4-Bromo-6-chloro-pyridine-2-carboxylic acid;MFCD13189210;SCHEMBL24581474;DTXSID70704407;AKOS017344877;AB67958;AC-27956;AS-50171;AM20050639;CS-0146050;FT-0688639;2-Pyridinecarboxylic acid, 4-bromo-6-chloro-;EN300-187940;O11188;A846807;Z1269179326

Suppliers and Price of 4-Bromo-6-chloropicolinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Bromo-6-chloro-2-pyridinecarboxylicAcid
10mg
$ 165.00

Crysdot
4-Bromo-6-chloropicolinicacid 95+%
250mg
$ 107.00

Crysdot
4-Bromo-6-chloropicolinicacid 95+%
1g
$ 323.00

Crysdot
4-Bromo-6-chloropicolinicacid 95+%
100mg
$ 70.00

Chemenu
4-bromo-6-chloropicolinicacid 95%
5g
$ 935.00

Chemenu
4-bromo-6-chloropicolinicacid 95%
25g
$ 2338.00

Chemenu
4-bromo-6-chloropicolinicacid 95%
10g
$ 1403.00

Ambeed
4-Bromo-6-chloropicolinicacid 97%
1g
$ 377.00

Ambeed
4-Bromo-6-chloropicolinicacid 97%
5g
$ 1389.00

Ambeed
4-Bromo-6-chloropicolinicacid 97%
250mg
$ 120.00

Total 34 raw suppliers

Chemical Property of 4-Bromo-6-chloropicolinic acid

Chemical Property:

Boiling Point:371.2±42.0 °C(Predicted)
PKA:2.88±0.10(Predicted)
PSA：50.19000
Density:1.917
LogP:2.19570
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:234.90357
Heavy Atom Count:11
Complexity:167

Purity/Quality:

99%, ^*data from raw suppliers

4-Bromo-6-chloro-2-pyridinecarboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C=C(N=C1C(=O)O)Cl)Br
Uses 4-Bromo-6-chloro-2-pyridinecarboxylic Acid, can be used in the synthesis of Naphthyridone p38 MAP kinase inhibitor, which is potentially useful for the treatment of rheumatoid arthritis and psoriasis.

Technology Process of 4-Bromo-6-chloropicolinic acid

There total 2 articles about 4-Bromo-6-chloropicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1206250-53-4
4-bromo-2-chloro-6-methylpyridine

: 1060805-66-4
4-bromo-6-chloropyridine-2-carboxylic acid

Guidance literature:: With potassium permanganate; water; sodium hydroxide; for 8h; Reagent/catalyst; Reflux;

Reference yield:

: 3749-51-7
2,4-dihydroxy-6-methylpyridine

: 1060805-66-4
4-bromo-6-chloropyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus(V) oxybromide / N,N-dimethyl-formamide / 3 h / 120 °C / Cooling with ice

2: trichlorophosphate / N,N-dimethyl-formamide / 8 h / 120 °C / Cooling with ice

3: potassium permanganate; sodium hydroxide; water / 8 h / Reflux

With potassium permanganate; water; sodium hydroxide; trichlorophosphate; phosphorus(V) oxybromide; In N,N-dimethyl-formamide;