2,4-Dihydroxy-6-methylpyridine

Base Information

• Chemical Name: 2,4-Dihydroxy-6-methylpyridine
• CAS No.: 3749-51-7
• Molecular Formula: C6H7NO2
• Molecular Weight: 125.127
• Hs Code.: 29333990
• Mol file: 3749-51-7.mol

Synonyms:2-hydroxy-6-methyl-1H-pyridin-4-one;6-Methylpyridine-2,4-diol;2,4-Dihydroxy-6-methylpyridine;

Chemical Property of 2,4-Dihydroxy-6-methylpyridine

Chemical Property:

• Appearance/Colour: beige powder
• Vapor Pressure: 0.00241mmHg at 25°C
• Melting Point: 324-327 °C
• Refractive Index: 1.563
• Boiling Point: 255.8 °C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 108.5 °C
• PSA: 53.09000
• Density: 1.269 g/cm³
• LogP: 0.38890
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Dihydroxy-6-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4-Dihydroxy-6-methylpyridine is a useful synthetic intermediate. It is used to prepare p38 kinase inhibitors. It is also used to synthesize Favipucine analogs with antimicrobial and fungicidal activities.

Technology Process of 2,4-Dihydroxy-6-methylpyridine

There total 17 articles about 2,4-Dihydroxy-6-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-hydroxy-6-methyl-2-pyron (675-10-5) → 4-hydroxy-6-methyl-2-pyridone (3749-51-7,4664-15-7)

Guidance literature:

With ammonium hydroxide; for 4h; Reflux;

DOI:10.1021/acs.jmedchem.5b00108

Reference yield:

C9H13NO3 (1332372-75-4) → 4-hydroxy-6-methyl-2-pyridone (3749-51-7,4664-15-7)

Guidance literature:

In toluene; for 4h; Reflux; Inert atmosphere;

DOI:10.1021/ol202028t

Reference yield:

1-amino-4-hydroxy-6-methyl-1H-pyridin-2-one → 4-hydroxy-6-methyl-2-pyridone (3749-51-7,4664-15-7)

Guidance literature:

With acetic acid; sodium nitrite; In water; for 4h;

DOI:10.3109/14756366.2012.694880

upstream raw materials:

2,4-diethoxy-6-methyl-pyridine

ethyl 2,4-dihydroxy-6-methylnicotinate

Dehydracetic acid

2,4-dichloro-6-methyl-pyridine

Downstream raw materials:

6-methyl-4-(N'-phenyl-hydrazino)-pyridin-2-ol

4,7-dimethyl-6H-pyrano[3,2-c]pyridine-2,5-dione

2,4-dimethoxy-6-methyl-pyridine

2-Methoxy-1,6-dimethyl-4-pyridone

Refernces

• 1、 Faidallah, Hassan M.,Rostom, Sherif A.F.,Khan, Khalid A.,Basaif, Salem A.. "Synthesis and characterization of some hydroxypyridone derivatives and their evaluation as antimicrobial agents". . p. 926 - 935. Retrieved 2013.
• 2、 Chen, Bingfeng,Xie, Zhenbing,Peng, Fangfang,Li, Shaopeng,Yang, Junjuan,Wu, Tianbin,Fan, Honglei,Zhang, Zhaofu,Hou, Minqiang,Li, Shumu,Liu, Huizhen,Han, Buxing. "Production of Piperidine and δ-Lactam Chemicals from Biomass-Derived Triacetic Acid Lactone". supporting information. p. 14405 - 14409. Retrieved 2021/05/21.
• 3、 Christoforow, Andreas,Wilke, Julian,Binici, Aylin,Pahl, Axel,Ostermann, Claude,Sievers, Sonja,Waldmann, Herbert. "Design, Synthesis, and Phenotypic Profiling of Pyrano-Furo-Pyridone Pseudo Natural Products". supporting information. p. 14715 - 14723. Retrieved 2019/09/06.