2,4-Dihydroxy-6-methylpyridine

Base Information

• Chemical Name: 2,4-Dihydroxy-6-methylpyridine
• CAS No.: 3749-51-7
• Molecular Formula: C6H7NO2
• Molecular Weight: 125.127
• Hs Code.: 29333990
• Mol file: 3749-51-7.mol

Synonyms:2-hydroxy-6-methyl-1H-pyridin-4-one;6-Methylpyridine-2,4-diol;2,4-Dihydroxy-6-methylpyridine;

Chemical Property of 2,4-Dihydroxy-6-methylpyridine

Chemical Property:

• Appearance/Colour: beige powder
• Vapor Pressure: 0.00241mmHg at 25°C
• Melting Point: 324-327 °C
• Refractive Index: 1.563
• Boiling Point: 255.8 °C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 108.5 °C
• PSA: 53.09000
• Density: 1.269 g/cm³
• LogP: 0.38890
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dihydroxy-6-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4-Dihydroxy-6-methylpyridine is a useful synthetic intermediate. It is used to prepare p38 kinase inhibitors. It is also used to synthesize Favipucine analogs with antimicrobial and fungicidal activities.

Technology Process of 2,4-Dihydroxy-6-methylpyridine

There total 17 articles about 2,4-Dihydroxy-6-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-hydroxy-6-methyl-2-pyron (675-10-5) → 4-hydroxy-6-methyl-2-pyridone (3749-51-7,4664-15-7)

Guidance literature:

With ammonium hydroxide; for 4h; Reflux;

DOI:10.1021/acs.jmedchem.5b00108

Reference yield:

C9H13NO3 (1332372-75-4) → 4-hydroxy-6-methyl-2-pyridone (3749-51-7,4664-15-7)

Guidance literature:

In toluene; for 4h; Reflux; Inert atmosphere;

DOI:10.1021/ol202028t

Reference yield:

1-amino-4-hydroxy-6-methyl-1H-pyridin-2-one → 4-hydroxy-6-methyl-2-pyridone (3749-51-7,4664-15-7)

Guidance literature:

With acetic acid; sodium nitrite; In water; for 4h;

DOI:10.3109/14756366.2012.694880

upstream raw materials:

2,4-diethoxy-6-methyl-pyridine

ethyl 2,4-dihydroxy-6-methylnicotinate

Dehydracetic acid

2,4-dichloro-6-methyl-pyridine

Downstream raw materials:

4-acetoxy-6-methyl-pyridin-2-ol

2,4-dibromo-6-methylpyridine

2,4-dichloro-6-methyl-pyridine

2-hydroxy-4-bromo-6-methylpyridine

Refernces

Synthesis of new azocompounds and fused pyrazolo[5,1-c][1,2,4]triazines using heterocyclic components

10.1002/jhet.1533

The study, titled "Synthesis of New Azocompounds and Fused Pyrazolo[5,1-c][1,2,4]triazines Using Heterocyclic Components," investigates the synthesis of new azocompounds and tricyclic pyrazolo[5,1-c][1,2,4]triazines using various heterocyclic components. The key chemical involved is 3-methyl-4-phenyl-1H-pyrazol-5-amine, which is diazotized to form pyrazole-3(5)-diazonium chloride. This diazonium salt undergoes azocoupling reactions with a variety of heterocyclic compounds, including barbituric acid, thiobarbituric acid, 2-hetarylpyrimidine-4,6-diones, 4-hydroxy-6-methylpyridin-2(1H)-one, 4-hydroxy-6-methyl-2H-pyran-2-one, 4-hydroxy-1-p-tolyl-1H-pyrazole-3-carboxylic acid ethyl ester, 1,3-thiazolidine-2,4-dione, and 2-thioxo-1,3-thiazolidin-4-one. These reactions yield new pyrazolylazo derivatives and fused pyrazolo[5,1-c][1,2,4]triazines through subsequent heterocyclization processes. The study explores the synthetic potential of these heterocyclic components in azocoupling reactions, highlighting their potential applications in industrial azo dyes, analytical indicators, and bioactive compounds related to purines.

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