WZ4002

Base Information

Chemical Name:WZ4002
CAS No.:1213269-23-8
Molecular Formula:C25H27ClN6O3
Molecular Weight:494.981
Hs Code.:
Mol file:1213269-23-8.mol

Synonyms:WZ-4002;

Suppliers and Price of WZ4002

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
WZ4002
250mg
$ 1260.00

Matrix Scientific
N-(3-(5-Chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide 97%
5g
$ 4050.00

Matrix Scientific
N-(3-(5-Chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide 97%
1g
$ 1350.00

DC Chemicals
WZ4002 >99%
1 g
$ 700.00

DC Chemicals
WZ4002 >99%
100 mg
$ 200.00

Crysdot
WZ4002 98+%
100mg
$ 443.00

ChemScene
WZ4002 99.69%
10mg
$ 84.00

ChemScene
WZ4002 99.69%
50mg
$ 240.00

ChemScene
WZ4002 99.69%
100mg
$ 420.00

Chemenu
N-(3-(5-Chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide 98%
100mg
$ 314.00

Total 76 raw suppliers

Chemical Property of WZ4002

Chemical Property:

PKA:12.78±0.70(Predicted)
PSA：95.34000
Density:1.314
LogP:5.27620
Solubility.:≥24.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

Purity/Quality:

99% ^*data from raw suppliers

WZ4002 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A novel mutant-selective EGFR kinase inhibitor of EGFRL858R and EGFRL858R/T790M with IC50s of 2 nM and 8 nM, respectively. WZ 4002 is an EGFR phosphorylation inhibitor.

Technology Process of WZ4002

There total 9 articles about WZ4002 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1213269-26-1
4-(3-aminophenoxy)-5-chloro-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl) pyrimidin-2-amine

: 814-68-6,25189-84-8
acryloyl chloride

: 1213269-23-8
N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1016/j.bmcl.2017.09.048

Reference yield:

: 122833-04-9
2-methoxy-4-(4-methylpiperazin-1-yl)aniline

: 1213269-23-8
N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / iso-butanol / 100 °C

2: platinum(IV) oxide; hydrogen / methanol

3: N-ethyl-N,N-diisopropylamine / dichloromethane

With platinum(IV) oxide; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; iso-butanol;
DOI:10.1016/j.bmcl.2010.12.036

Reference yield:

: 76661-24-0
2,5-dichloro-4-(3-nitrophenoxy)pyrimidine

: 1213269-23-8
N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / iso-butanol / 100 °C

2: platinum(IV) oxide; hydrogen / methanol

3: N-ethyl-N,N-diisopropylamine / dichloromethane

With platinum(IV) oxide; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; iso-butanol;
DOI:10.1016/j.bmcl.2010.12.036