tert-butyl 4-(6-aMinopyridin-3-yl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(6-aMinopyridin-3-yl)piperidine-1-carboxylate
• CAS No.: 1198408-35-3
• Molecular Formula: C₁₅H₂₃N₃O₂
• Molecular Weight: 277.367
• Hs Code.: 2933990090
• Mol file: 1198408-35-3.mol

Synonyms:6-amino-3',4',5',6'-tetrahydro-2'H-3,4'-bipyridinyl-1'-carboxylic acid tert-butyl ester

Chemical Property of tert-butyl 4-(6-aMinopyridin-3-yl)piperidine-1-carboxylate

Chemical Property:

• Boiling Point: 422.8±45.0 °C(Predicted)
• PKA: 6.80±0.26(Predicted)
• PSA: 69.18000
• Density: 1.134±0.06 g/cm3(Predicted)
• LogP: 2.64630
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl4-(6-Aminopyridin-3-yl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(6-aMinopyridin-3-yl)piperidine-1-carboxylate

There total 33 articles about tert-butyl 4-(6-aMinopyridin-3-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 6-nitropyridine-3′,6′-dihydro-[3,4′-pyridine]-1′(2′H)-carboxylate (1231930-22-5) → 6-amino-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'-carboxylic acid tert-butyl ester (1198408-35-3)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; ethyl acetate;

Reference yield: 95.4%

tert-butyl 6-amino-3’,6’-dihydro-[3,4’-bipyridine]-1'(2’H)-carboxylate (1279030-84-0) → 6-amino-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'-carboxylic acid tert-butyl ester (1198408-35-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; ammonium formate; In isopropyl alcohol; at 20 - 30 ℃; Inert atmosphere;

Reference yield: 95.0%

C15H21N3O4 → 6-amino-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'-carboxylic acid tert-butyl ester (1198408-35-3)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; ethanol; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2017.12.003

upstream raw materials:

tert-butyl 6-amino-3’,6’-dihydro-[3,4’-bipyridine]-1'(2’H)-carboxylate

tert-butyl 6-nitropyridine-3′,6′-dihydro-[3,4′-pyridine]-1′(2′H)-carboxylate

5-bromo-2-pyridylamine

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

Downstream raw materials:

C₂₄H₂₇ClN₄O₃

C₄₁H₄₆FN₇O₆

2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(1-methyl-5-(5-(1-methylpiperidin-4-yl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(5-(5-(1-ethylpiperidin-4-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

Refernces

• 1、 -. "SUBSTITUTED PYRROLOPYRIMIDINE CDK INHIBITOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME AND USE THEREOF". Paragraph 0096; 0097. . Retrieved 2019/02/09.
• 2、 -. "PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITOR OF CYCLIN DEPENDENT KINASE". Page/Page column 50; 54. . Retrieved 2019/11/04.