1-(Pyridin-2-yl)cyclopropanamine

Base Information

• Chemical Name: 1-(Pyridin-2-yl)cyclopropanamine
• CAS No.: 503417-37-6
• Molecular Formula: C8H10N2
• Molecular Weight: 134.181
• Hs Code.: 2933399090
• European Community (EC) Number: 821-927-4
• DSSTox Substance ID: DTXSID30455286
• Nikkaji Number: J1.765.805K
• Wikidata: Q72504140
• ChEMBL ID: CHEMBL4542870
• Mol file: 503417-37-6.mol

Synonyms:1-(pyridin-2-yl)cyclopropanamine;503417-37-6;1-PYRIDIN-2-YL-CYCLOPROPYLAMINE;1-pyridin-2-ylcyclopropan-1-amine;1-(2-PYRIDYL)CYCLOPROPYLAMINE;1-(2-Pyridyl)cyclopropanamine;MFCD08059320;CYCLOPROPANAMINE, 1-(2-PYRIDINYL)-;1-(PYRIDIN-2-YL)CYCLOPROPAN-1-AMINE;SCHEMBL526425;1-pyridin-2-ylcyclopropanamine;1-Pyridin-2-ylcyclopropylamine;2-(1-aminocyclopropyl)pyridine;CHEMBL4542870;AMY5595;DTXSID30455286;HRVLXTZHPZXHTR-UHFFFAOYSA-N;1-(pyridin-2-yl) cyclopropanamine;AKOS011971877;AB43090;AC-22779;Cyclopropanamine,1-(2-pyridinyl)-(9CI);SY012362;FT-0690047;A22976;EN300-201803;Z995042286;1-(2-Pyridyl)cyclopropylamine

Chemical Property of 1-(Pyridin-2-yl)cyclopropanamine

Chemical Property:

• Vapor Pressure: 0.042mmHg at 25°C
• Melting Point: 62ºC
• Refractive Index: 1.599
• Boiling Point: 238.782 °C at 760 mmHg
• PKA: 7.82±0.20(Predicted)
• Flash Point: 121.322 °C
• PSA: 38.91000
• Density: 1.15 g/cm³
• LogP: 1.72970
• Storage Temp.: 2-8°C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 134.084398327
• Heavy Atom Count: 10
• Complexity: 129

Purity/Quality:

99.5% ^*data from raw suppliers

1-(Pyridin-2-yl)cyclopropanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC1(C2=CC=CC=N2)N

Technology Process of 1-(Pyridin-2-yl)cyclopropanamine

There total 5 articles about 1-(Pyridin-2-yl)cyclopropanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-Cyanopyridine (100-70-9,1232006-36-8) + diethylzinc (557-20-0) → 1-(pyridin-2-yl)cyclopropan-1-amine (503417-37-6)

Guidance literature:

With methyltriisopropoxytitanium(IV); lithium isopropoxide; lithium iodide; In tetrahydrofuran; at 20 ℃; for 8h;

DOI:10.1021/ol034021k

Reference yield: 57.0%

2-Cyanopyridine (100-70-9,1232006-36-8) + ethylmagnesium bromide (925-90-6) → 1-(pyridin-2-yl)cyclopropan-1-amine (503417-37-6)

Guidance literature:

With titanium(IV) isopropylate; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1021/jo025634y

Reference yield: 20.0%

1-(pyridin-2-yl)cyclopropanecarboxylic acid (162960-26-1) → 1-(pyridin-2-yl)cyclopropan-1-amine (503417-37-6)

Guidance literature:

1-(pyridin-2-yl)cyclopropanecarboxylic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; at 90 ℃;

With methanol; sodium hydroxide; water; at 70 ℃; for 3h;

upstream raw materials:

2-Cyanopyridine

ethylmagnesium bromide

diethylzinc

1-(pyridin-2-yl)cyclopropanecarboxylic acid

Downstream raw materials:

N-(1-(pyridin-2-yl)cyclopropyl)benzene-1,4-diamine

2-(4-((1-(pyridin-2-yl)cyclopropyl)amino)phenyl)benzo[d][1,3,2]dithiazole 1,1,3,3-tetraoxide

N-(1-(pyridin-2-yl)cyclopropyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

6-(N-ethylmethylsulfonamido)-2-(4-fluorophenyl)-N-methyl-5-(3-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide

Refernces

• 1、 -. "5-FLUORONICOTINAMIDE DERIVATIVES AND USES THEREOF". Paragraph 00454-00457. . Retrieved 2021/04/10.
• 2、 -. "BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS". Page/Page column 77. . Retrieved 2011/06/16.