tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate
• CAS No.: 1215071-17-2
• Molecular Formula: C10H15F2NO3
• Molecular Weight: 235.231
• Hs Code.: 2933399090
• Mol file: 1215071-17-2.mol

Synonyms:1-Piperidinecarboxylic acid, 3,3-difluoro-4-oxo-, 1,1-diMethylethyl ester;tert-Butyl 3,3-difluoro-4-oxopiperidin-1-carboxylate hydrate;tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate hydrate

Chemical Property of tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate

Chemical Property:

• Boiling Point: 274.7±40.0 °C(Predicted)
• PKA: -5?+-.0.40(Predicted)
• PSA: 46.61000
• Density: 1.21±0.1 g/cm3(Predicted)
• LogP: 1.76950

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl3,3-Difluoro-4-oxopiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate

There total 10 articles about tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

di-tert-butyl dicarbonate (24424-99-5) + 1-benzyl-3,3-difluoropiperidin-4-one (1039741-54-2) → tert-butyl 3,3-difluoro-4-oxo-piperidine-1-carboxylate (1215071-17-2)

Guidance literature:

With hydrogen; palladium(II) hydroxide; In ethanol; at 20 ℃; for 20h;

Reference yield:

tert-butyl 3,3-difluoro-4-hydroxy-piperidine-1-carboxylate (1209780-71-1,1893408-11-1,1893408-14-4) → tert-butyl 3,3-difluoro-4-oxo-piperidine-1-carboxylate (1215071-17-2)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; Inert atmosphere; cooling with ice;

Reference yield:

iminodicarboxylic acid di-tert-butyl ester (51779-32-9) + 3,3-difluoropiperidin-4-one hydrochloride (1523618-12-3) → tert-butyl 3,3-difluoro-4-oxo-piperidine-1-carboxylate (1215071-17-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/j.tetlet.2012.12.115

upstream raw materials:

di-tert-butyl dicarbonate

3,3-difluoro-1-(phenylmethyl)-4,4-piperidinediol

tert-butyl 3,3-difluoro-4-hydroxy-piperidine-1-carboxylate

N-benzyl-3,3-difluoro-4-hydroxypiperidine

Downstream raw materials:

tert-butyl 4-(2-ethoxy-2-oxoethyl)-3,3-difluoropiperidine-1-carboxylate

C₁₆H₁₉BrF₂N₂O₂

C₁₇H₂₁BrF₂N₂O₂

C₁₇H₂₁BrF₂N₂O₂

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