1-Piperidinecarboxylic acid, 3,3-difluoro-4-hydroxy-, 1,1-diMethylethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 3,3-difluoro-4-hydroxy-, 1,1-diMethylethyl ester
• CAS No.: 1209780-71-1
• Molecular Formula: C10H17F2NO3
• Molecular Weight: 237.247
• Hs Code.: 2933399090
• Mol file: 1209780-71-1.mol

Synonyms:1-Piperidinecarboxylic acid, 3,3-difluoro-4-hydroxy-, 1,1-diMethylethyl ester;1-Boc-3,3-difluoro-4-hydr...;tert-butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate;1-Boc-3,3-difluoro-4-hydroxypiperidine;3,3-Difluoro-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property of 1-Piperidinecarboxylic acid, 3,3-difluoro-4-hydroxy-, 1,1-diMethylethyl ester

Chemical Property:

• PSA: 49.77000
• LogP: 1.56130
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3,3-Difluoro-4-hydroxypiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 3,3-difluoro-4-hydroxy-, 1,1-diMethylethyl ester

There total 6 articles about 1-Piperidinecarboxylic acid, 3,3-difluoro-4-hydroxy-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.1%

di-tert-butyl dicarbonate (24424-99-5) + 3,3-difluoropiperidin-4-ol (1239596-54-3) → tert-butyl 3,3-difluoro-4-hydroxy-piperidine-1-carboxylate (1209780-71-1,1893408-11-1,1893408-14-4)

Guidance literature:

In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

tert-butyl 3,3-difluoro-4,4-dihydroxypiperidine-1-carboxylate (1067914-83-3) → tert-butyl 3,3-difluoro-4-hydroxy-piperidine-1-carboxylate (1209780-71-1,1893408-11-1,1893408-14-4)

Guidance literature:

tert-butyl 3,3-difluoro-4,4-dihydroxypiperidine-1-carboxylate; With sodium tetrahydroborate; In ethanol; at 20 ℃; for 3h;

With hydrogenchloride; In ethanol; water; at 20 ℃; for 0.333333h; pH=3 - 4;

With sodium hydrogencarbonate; In ethanol; water;

Reference yield:

3,3-difluoro-1-(phenylmethyl)-4,4-piperidinediol (1067914-81-1) → tert-butyl 3,3-difluoro-4-hydroxy-piperidine-1-carboxylate (1209780-71-1,1893408-11-1,1893408-14-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate; methanol / 0.25 h / 0 °C / Inert atmosphere

2: hydrogen / palladium(II) hydroxide / ethanol / 20 °C

3: dichloromethane / 2 h / 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; hydrogen; palladium(II) hydroxide; In ethanol; dichloromethane;

upstream raw materials:

tert-butyl 3,3-difluoro-4,4-dihydroxypiperidine-1-carboxylate

di-tert-butyl dicarbonate

3,3-difluoropiperidin-4-ol

3,3-difluoro-1-(phenylmethyl)-4,4-piperidinediol

Downstream raw materials:

tert-butyl 3,3-difluoro-4-oxo-piperidine-1-carboxylate

tert-butyl 4-(2-ethoxy-2-oxoethyl)-3,3-difluoropiperidine-1-carboxylate

tert-butyl 3,3-difluoro-4,4-dihydroxypiperidine-1-carboxylate

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