(S)-5-AMINO-PIPERIDIN-2-ONE HCL

Base Information

• Chemical Name: (S)-5-AMINO-PIPERIDIN-2-ONE HCL
• CAS No.: 672883-95-3
• Molecular Formula: C5H10N2O.ClH
• Molecular Weight: 150.608
• Hs Code.: 2933399990
• Mol file: 672883-95-3.mol

Synonyms:4-(S)-AMINO-D-VALEROLACTAM HCL;(S)-5-AMINO-PIPERIDIN-2-ONE HCL;(S)-5-AMINOPIPERIDIN-2-ONE HYDROCHLORIDE;2-Piperidinone, 5-amino-, monohydrochloride, (5S)-;(S)-5-AMINO-PIPERIDIN-2-ONEHCL (MFCD03094719);(S)-4-Amino-delta-valerolactam hydrochloride

Chemical Property of (S)-5-AMINO-PIPERIDIN-2-ONE HCL

Chemical Property:

• PSA: 55.12000
• LogP: 1.05480
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(S)-5-Aminopiperidin-2-onehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-5-AMINO-PIPERIDIN-2-ONE HCL

There total 1 articles about (S)-5-AMINO-PIPERIDIN-2-ONE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5S)-5-[(tert-butoxycarbonyl)amino]piperidin-2-one (172913-96-1,1228566-94-6) → 4-(S)-amino-δ-valerolactam hydrochloride (672883-95-3)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 3h;

Reference yield:

4-(S)-amino-δ-valerolactam hydrochloride (672883-95-3) + benzyl bromide (100-39-0) → (5S)-5-(N,N-dibenzylamino)piperidin-2-one (309912-57-0)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; at 80 ℃; for 8h;

Reference yield:

4-(S)-amino-δ-valerolactam hydrochloride (672883-95-3) + (S)-5-((4-chloro-5-((4-(3-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methylphenyl)-2,3-dihydro-1H-inden-1-yl)oxy)-2-formylphenoxy)methyl)isophthalonitrile → 5-((4-chloro-5-(((S)-4-(3-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methylphenyl)-2,3-dihydro-1H-inden-1-yl)oxy)-2-((((S)-6-oxopiperidin-3-yl)amino)methyl)phenoxy)methyl)isophthalonitrile

Guidance literature:

4-(S)-amino-δ-valerolactam hydrochloride; (S)-5-((4-chloro-5-((4-(3-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methylphenyl)-2,3-dihydro-1H-inden-1-yl)oxy)-2-formylphenoxy)methyl)isophthalonitrile; In N,N-dimethyl-formamide; for 1h;

With sodium tris(acetoxy)borohydride; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

(5S)-5-[(tert-butoxycarbonyl)amino]piperidin-2-one

Downstream raw materials:

(3S)-3-(3-cyclopentyloxy-4-difluoromethoxyphenylcarboxamido)-6-oxohexahydropyridine

(3S)-3-(3-cyclopropylmethyloxy-4-difluoromethoxyphenylcarboxamido)-6-oxo-hexahydropyridine

(3S)-3-[3,4-di(difluoromethoxy)phenylcarboxamido]-6-oxohexahydropyridine

(3S)-3-(3-cyclopentyloxy-4-methoxyphenylcarboxamido)-6-oxohexahydropyridine