1-PYRAZIN-2-YL-ETHYLAMINE

Base Information

• Chemical Name: 1-PYRAZIN-2-YL-ETHYLAMINE
• CAS No.: 179323-60-5
• Molecular Formula: C6H9N3
• Molecular Weight: 123.158
• Hs Code.: 2933990090
• Mol file: 179323-60-5.mol

Synonyms:1-PYRAZIN-2-YL-ETHYLAMINE;1-(Pyrazin-2-yl)ethanamine;2-Pyrazinemethanamine, .alpha.-methyl-;1-(pyrazin-2-yl)ethan-1-aMine;alpha-Methyl-2-pyrazinemethanamine

Chemical Property of 1-PYRAZIN-2-YL-ETHYLAMINE

Chemical Property:

• Boiling Point: 215.0±25.0 °C(Predicted)
• PKA: 8.19±0.40(Predicted)
• PSA: 51.80000
• Density: 1.088±0.06 g/cm3(Predicted)
• LogP: 1.19660
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%Min ^*data from raw suppliers

1-(Pyrazin-2-yl)ethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(Pyrazin-2-yl)ethylamine is a pyrazine derivative and a potential beta3-adrenoceptor agonist.

Technology Process of 1-PYRAZIN-2-YL-ETHYLAMINE

There total 2 articles about 1-PYRAZIN-2-YL-ETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

acetylpyrazine (22047-25-2) → 1-(pyrazin-2-yl)ethan-1-amine (179323-60-5)

Guidance literature:

acetylpyrazine; With ammonium acetate; sodium cyanoborohydride; In methanol; at 20 ℃;

With sodium hydroxide; water; pH=13;

Reference yield: 60.0%

→ 1-(pyrazin-2-yl)ethan-1-amine (179323-60-5)

Guidance literature:

Reference yield:

1-(pyrazin-2-yl)ethan-1-amine (179323-60-5) + 4'-methyl-5-(2-oxo-benzooxazol-3-yl)-biphenyl-3-carboxylic acid (1258950-63-8) → 4'-Methyl-5-(2-oxo-benzooxazol-3-yl)-biphenyl-3-carboxylic acid (1-pyrazin-2-yl-ethyl)-amide (1258950-55-8)

Guidance literature:

With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

acetylpyrazine

Downstream raw materials:

4'-Methyl-5-(2-oxo-benzooxazol-3-yl)-biphenyl-3-carboxylic acid (1-pyrazin-2-yl-ethyl)-amide

Refernces

• 1、 -. "NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS". Page/Page column 50. . Retrieved 2011/04/14.
• 2、 -. "OXAZOLONE AND PYRROLIDINONE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS". Page/Page column 24. . Retrieved 2010/12/31.