2-(4-Fluorophenyl)-2,3-dihydro-4(1H)-quinolinone

Base Information

• Chemical Name: 2-(4-Fluorophenyl)-2,3-dihydro-4(1H)-quinolinone
• CAS No.: 155370-03-9
• Molecular Formula: C15H12FNO
• Molecular Weight: 241.265
• DSSTox Substance ID: DTXSID00587801
• Nikkaji Number: J1.243.985G
• Mol file: 155370-03-9.mol

Synonyms:2-(4-Fluorophenyl)-2,3-dihydro-4(1H)-quinolinone;155370-03-9;2-(4-fluorophenyl)-2,3-dihydro-1H-quinolin-4-one;2-(4-fluorophenyl)-2,3-dihydroquinolin-4(1H)-one;2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinolin-4-one;SCHEMBL3736556;4(1H)-Quinolinone, 2-(4-fluorophenyl)-2,3-dihydro-;DTXSID00587801;HQCCOFMBOJBRQY-UHFFFAOYSA-N;AMY28848;MFCD09999181;AKOS015853437;DS-0359;FS-2775;CS-0318492;A883656;J-505986

Chemical Property of 2-(4-Fluorophenyl)-2,3-dihydro-4(1H)-quinolinone

Chemical Property:

• Vapor Pressure: 7.86E-07mmHg at 25°C
• Melting Point: 134 °C
• Boiling Point: 406.9°C at 760 mmHg
• PKA: 1.86±0.40(Predicted)
• Flash Point: 199.9°C
• PSA: 29.10000
• Density: 1.223g/cm³
• LogP: 3.70330
• Storage Temp.: 2-8°C
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 241.090292168
• Heavy Atom Count: 18
• Complexity: 312

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Fluorophenyl)-2,3-dihydro-4(1H)-quinolinone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(NC2=CC=CC=C2C1=O)C3=CC=C(C=C3)F

Technology Process of 2-(4-Fluorophenyl)-2,3-dihydro-4(1H)-quinolinone

There total 12 articles about 2-(4-Fluorophenyl)-2,3-dihydro-4(1H)-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-(2-aminophenyl)-3-(4-fluorophenyl)prop-2-en-1-one (262606-35-9) → 2-(4-fluorophenyl)-1,2,3,4-tetrahydro-4-quinolone (155370-03-9)

Guidance literature:

With SbCl₃-impregnated silica gel; at 100 ℃; for 0.166667h; Neat (no solvent);

DOI:10.1080/00397910902985523

Reference yield: 96.0%

trans-1-(2-aminophenyl)-3-(4-fluorophenyl)-prop-2-en-1-one (156492-25-0) → 2-(4-fluorophenyl)-1,2,3,4-tetrahydro-4-quinolone (155370-03-9)

Guidance literature:

alumina supported CeCl₃*7H₂O-NaI; at 70 ℃;

DOI:10.1016/j.tetlet.2006.11.020

Reference yield: 94.0%

4-fluorobenzaldehyde (459-57-4) + 2-aminoacetophenone (551-93-9) → 2-(4-fluorophenyl)-1,2,3,4-tetrahydro-4-quinolone (155370-03-9)

Guidance literature:

With C₂₂H₄₈N₄O₁₂S₄⁽⁴⁺⁾*4HO₄S^(1-); In ethanol; water; at 20 ℃; for 1.6h; Irradiation; Reflux;

upstream raw materials:

trans-1-(2-aminophenyl)-3-(4-fluorophenyl)-prop-2-en-1-one

4-fluorobenzaldehyde

2-aminoacetophenone

1-(2-aminophenyl)-3-(4-fluorophenyl)prop-2-en-1-one

Downstream raw materials:

2-(4-fluorophenyl)-1,2,3,4-tetrahydro-1,4-benzodiazepin-5-one

2-(4-fluorophenyl)-3-((pyridin-4-yl)methyl)quinolin-4(1H)-one

1-acetyl-2-(4-fluorophenyl)-2,3-dihydroquinolin-4(1H)-one

2-(4-fluorophenyl)-6,8-diphenyl-2,3-dihydroquinolin-4(1H)-one

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