LTBx

Base Information

Chemical Name:LTBx
CAS No.:79056-01-2
Molecular Formula:C20H32O4
Molecular Weight:336.47
Hs Code.:

Synonyms:(5S,12S,6E,8Z,10E,14Z)-5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid;5S,12S-dihydroxy-6,10-E,8,14-Z-eicosatetraenoic acid;5S,12S-diHETE (LTBx);5S,12S-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid;(6E,8Z,10E,14Z)-(5S,12S)-5,12-Dihydroxy-icosa-6,8,10,14-tetraenoic acid;

Suppliers and Price of LTBx

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
LeukotrieneBx
50g
$ 1000.00

Cayman Chemical
5(S),12(S)-DiHETE ≥98%
100μg
$ 475.00

Cayman Chemical
5(S),12(S)-DiHETE ≥98%
50μg
$ 251.00

Cayman Chemical
5(S),12(S)-DiHETE ≥98%
25μg
$ 132.00

Total 2 raw suppliers

Chemical Property of LTBx

Chemical Property:

PSA：77.76000
LogP:4.15830

Purity/Quality:

99% ^*data from raw suppliers

LeukotrieneBx ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Leukotriene Bx is a natural lipid derived from Arachidonic Acid (A765000), which is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides.

Technology Process of LTBx

There total 124 articles about LTBx which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66753-05-7
<5,6,8,9,11,12,14,15-3H8>arachidonic acid

: 71160-24-2
Leukotriene B

: 70578-51-7,71160-24-2,71548-19-1,73151-67-4,77367-60-3,79056-01-2,79065-06-8,79083-59-3,79083-60-6,79897-16-8,82978-32-3,82978-33-4,83709-73-3,86161-62-8,86161-63-9,88643-26-9,90529-29-6,90638-64-5,101759-15-3,101759-16-4,108392-55-8,108392-56-9,117020-67-4,128946-47-4,128946-48-5,139560-82-0,71652-82-9
6-trans-Leukotriene B₄

: 61641-47-2,70608-72-9,71030-39-2,71774-09-9,72255-35-7,73307-52-5,74080-72-1,88588-79-8
5(S)-HETE

: 70578-51-7,71160-24-2,71548-19-1,71652-82-9,73151-67-4,77367-60-3,79065-06-8,79083-59-3,79083-60-6,79897-16-8,82978-32-3,82978-33-4,83709-73-3,86161-62-8,86161-63-9,88643-26-9,90529-29-6,90638-64-5,101759-15-3,101759-16-4,108392-55-8,108392-56-9,117020-67-4,128946-47-4,128946-48-5,139560-82-0,79056-01-2
(5S,12S,6E,8Z,10E,14Z)-5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid

Guidance literature:: With ATP; calcium(II) nitrate; edetate disodium; In phosphate buffer; water; at 30 ℃; for 0.25h; pH=7.4; Further byproducts.;
DOI:10.1002/jlcr.1488

Reference yield:

: 66753-05-7
<5,6,8,9,11,12,14,15-3H8>arachidonic acid

: 71160-24-2
Leukotriene B

: 70578-51-7,71160-24-2,71548-19-1,73151-67-4,77367-60-3,79056-01-2,79065-06-8,79083-59-3,79083-60-6,79897-16-8,82978-32-3,82978-33-4,83709-73-3,86161-62-8,86161-63-9,88643-26-9,90529-29-6,90638-64-5,101759-15-3,101759-16-4,108392-55-8,108392-56-9,117020-67-4,128946-47-4,128946-48-5,139560-82-0,71652-82-9
6-trans-Leukotriene B₄

: 61641-47-2,70608-72-9,71030-39-2,71774-09-9,72255-35-7,73307-52-5,74080-72-1,88588-79-8
5(S)-HETE

: 70578-51-7,71160-24-2,71548-19-1,71652-82-9,73151-67-4,77367-60-3,79065-06-8,79083-59-3,79083-60-6,79897-16-8,82978-32-3,82978-33-4,83709-73-3,86161-62-8,86161-63-9,88643-26-9,90529-29-6,90638-64-5,101759-15-3,101759-16-4,108392-55-8,108392-56-9,117020-67-4,128946-47-4,128946-48-5,139560-82-0,79056-01-2
(5S,12S,6E,8Z,10E,14Z)-5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid

Guidance literature:: With ATP; calcium(II) nitrate; edetate disodium; In phosphate buffer; water; at 30 ℃; for 0.25h; pH=7.4; Further byproducts.;
DOI:10.1002/jlcr.1488

Reference yield:

: 76745-14-7
(E)-4-((4S,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-2-enoic acid methyl ester

: 70578-51-7,71160-24-2,71548-19-1,73151-67-4,77367-60-3,79056-01-2,79065-06-8,79083-59-3,79083-60-6,79897-16-8,82978-32-3,82978-33-4,83709-73-3,86161-62-8,86161-63-9,88643-26-9,90529-29-6,90638-64-5,101759-15-3,101759-16-4,108392-55-8,108392-56-9,117020-67-4,128946-47-4,128946-48-5,139560-82-0,71652-82-9
6-trans-Leukotriene B₄

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen / 10percent palladium-on-charcoal / ethyl acetate / 4 h / 23 °C

2: pyridine / 12 h / 23 °C

3: 1.) 2percent methanolic HCl, 2.) potassium carbonate / 1.) 23 deg C, 7 h, 2.) methanol, 23 deg C, 30 min

4: pyridine / 1 h / 23 °C

5: 1.) 70percent perchloric acid, dimethyl carbonate, 2.) lead tetracetate, sodium carbonate / 1.) water, 23 deg C, 4 h, 2.) methylene chloride, -40 deg C, 10 min

6: 32 percent / n-butyllithium, HMPA / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) -78 deg C -> -20 deg C, 30 min, 3.) -20 deg C -> 0 deg C, 30 min

7: 1.) potassium carbonate, 2.) lithium hydroxide / 1.) methanol, 25 deg C, 6.5 h, 2.) methanol-water (2:1) 23 deg C, 1 h

With lead(IV) acetate; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hydroxide; n-butyllithium; perchloric acid; hydrogen; sodium carbonate; potassium carbonate; carbonic acid dimethyl ester; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethyl acetate;
DOI:10.1021/ja00547a051