N-(1-Phenylethyl)benzenesulfonamide

Base Information

• Chemical Name: N-(1-Phenylethyl)benzenesulfonamide
• CAS No.: 1146-47-0
• Molecular Formula: C14H15 N O2 S
• Molecular Weight: 261.345
• Hs Code.: 2935009090
• NSC Number: 296509
• Nikkaji Number: J2.405.898K
• Mol file: 1146-47-0.mol

Synonyms:N-(1-Phenylethyl)benzenesulfonamide;1146-47-0;Benzenesulfonamide, N-(1-phenylethyl)-;N-(1-Phenylethyl)benzenesulfonaMide, 97per cent;NSC296509;NSC 296509;Cambridge id 5121957;Oprea1_334752;Oprea1_522200;CBDivE_001901;CBDivE_002647;SCHEMBL3759433;HMS1579O06;AKOS001064870;AKOS016324555;NSC-296509;N-(1-PHENYL-ETHYL)-BENZENESULFONAMIDE;SR-01000196992;SR-01000196992-1;Z45507988

Chemical Property of N-(1-Phenylethyl)benzenesulfonamide

Chemical Property:

• Vapor Pressure: 7.26E-07mmHg at 25°C
• Boiling Point: 407.9°Cat760mmHg
• Flash Point: 200.5°C
• PSA: 54.55000
• Density: 1.198g/cm³
• LogP: 4.19780
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 261.08234989
• Heavy Atom Count: 18
• Complexity: 335

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(1-PHENYL-ETHYL)-BENZENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=CC=C1)NS(=O)(=O)C2=CC=CC=C2

Technology Process of N-(1-Phenylethyl)benzenesulfonamide

There total 30 articles about N-(1-Phenylethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

sodium benzoate (532-32-1) + (S)-1-phenyl-ethylamine (2627-86-3) → (S)-N-(1-phenylethyl)benzenesulfonamide (1146-47-0)

Guidance literature:

With lithium perchlorate; In water; acetonitrile; for 1h; Electrochemical reaction;

DOI:10.1039/d0gc01360a

Reference yield: 93.0%

benzenesulfonamide (98-10-2) + 1-phenylethyl acetate (93-92-5,50373-55-2) → N-(α-methylbenzyl)benzenesulfonamide (1146-47-0)

Guidance literature:

With t-BuOOAc; copper(II) bis(trifluoromethanesulfonate); In 1,2-dichloro-ethane; at 60 ℃; for 6h;

DOI:10.1016/j.tetlet.2008.02.135

Reference yield: 90.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + benzenesulfonamide (98-10-2) → N-(α-methylbenzyl)benzenesulfonamide (1146-47-0)

Guidance literature:

With iodine; In toluene; at 110 ℃; for 2.5h;

DOI:10.1016/j.tetlet.2009.07.010

upstream raw materials:

benzenesulfonyl chloride

rac-methylbenzylamine

N-benzylidenephenylsulfonamide

methylmagnesium bromide

Downstream raw materials:

N-methyl-N-(α-methylbenzyl)benzenesulfonamide

N-Ethyl-N-(1-phenyl-ethyl)-benzenesulfonamide

N-(1-Phenyl-ethyl)-N-prop-2-ynyl-benzenesulfonamide

N-(2-methyl-2,3-epoxypropyl)-N-(α-methylbenzyl)benzenesulfonamide

Refernces

• 1、 Payard, Pierre-Adrien,Gu, Qingyi,Guo, Wenping,Wang, Qianran,Corbet, Matthieu,Michel, Carine,Sautet, Philippe,Grimaud, Laurence,Wischert, Raphael,Pera-Titus, Marc. "Direct Amination of Alcohols Catalyzed by Aluminum Triflate: An Experimental and Computational Study". . p. 14146 - 14153. Retrieved 2018.
• 2、 Cheruku, Srinivas,Manikyanally, Kumara N.,Mantelingu, Kempegowda,Nagarakere, Sandhya C.,Narayana, Yatheesh,Rangappa, Kanchugarakoppal S.,Sunilkumar, Makanahalli P.. "An expedient, efficient and solvent-free synthesis of T3P-mediated amidation of benzhydrols with poorly reactive N-nucleophiles under MW irradiation". . p. 4421 - 4426. Retrieved 2022/03/14.
• 3、 Alom, Nur-E,Ariyarathna, Jeewani P.,Bassiouni, Omar H.,Kaur, Navdeep,Kennell, Maureen L.,Li, Wei,Wu, Fan. "Halogen-Bond-Induced Consecutive Csp3-H Aminations via Hydrogen Atom Transfer Relay Strategy". . p. 2135 - 2140. Retrieved 2020/04/09.