4-Demethylaristolone

Base Information

• Chemical Name: 4-Demethylaristolone
• CAS No.: 26548-50-5
• Molecular Formula: C₁₄H₂₀O
• Molecular Weight: 204.312
• Mol file: 26548-50-5.mol

Synonyms:2H-Cyclopropa[a]naphthalen-2-one,1,1a,4,5,6,7,7a,7b-octahydro-1,1,7a-trimethyl-, (1aa,7aa,7ba)-;2H-Cyclopropa[a]naphthalen-2-one, 1,1ab,4,5,6,7,7a,7bb-octahydro-1,1,7ab-trimethyl- (8CI); 4-Demethylaristolone; Aristolone,4-demethyl-

Chemical Property of 4-Demethylaristolone

Chemical Property:

• PSA: 17.07000
• LogP: 3.34800

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Demethylaristolone

There total 12 articles about 4-Demethylaristolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-butylthiomethylenecyclohexanone (32116-70-4) → (+/-)-4-Demethylaristolon (19906-56-0,26548-50-5)

Guidance literature:

Multi-step reaction with 5 steps

1: (i) KOtBu, (ii) /BRN= 878160/

2: aq. KOH / ethane-1,2-diol / Heating

3: TsOH / benzene / Heating

4: (i) NaH, (ii) /BRN= 6694963/, (iii) aq. KOH

With potassium hydroxide; toluene-4-sulfonic acid; In ethylene glycol; benzene;

DOI:10.1139/v69-713

Reference yield:

2-butylthiomethylenecyclohexanone (32116-70-4) → (+/-)-5-Epi-4-demethylaristolon (19906-56-0,26548-50-5)

Guidance literature:

Multi-step reaction with 5 steps

1: (i) KOtBu, (ii) /BRN= 878160/

2: aq. KOH / ethane-1,2-diol / Heating

3: TsOH / benzene / Heating

4: (i) NaH, (ii) /BRN= 6694963/, (iii) aq. KOH

With potassium hydroxide; toluene-4-sulfonic acid; In ethylene glycol; benzene;

DOI:10.1139/v69-713

Reference yield:

2-methyl-2-(2-methyl-2-propenyl)cyclohexanone (65898-71-7) → (+/-)-4-Demethylaristolon (19906-56-0,26548-50-5)

Guidance literature:

Multi-step reaction with 3 steps

1: TsOH / benzene / Heating

2: (i) NaH, (ii) /BRN= 6694963/, (iii) aq. KOH

With toluene-4-sulfonic acid; In benzene;

DOI:10.1139/v69-713

upstream raw materials:

diazomethane

2-Carboxymethyl-3-methyl-3-methylpropenyl-cyclohexen

2-butylthiomethylenecyclohexanone

2-methyl-2-(2-methyl-2-propenyl)cyclohexanone